Circadian rhythms, intrinsic cycles spanning approximately 24 h, regulate numerous physiological processes, including sleep-wake cycles, hormone release, and metabolism. These rhythms are orchestrated by the circadian clock, primarily located in the suprachiasmatic nucleus (SCN) of the hypothalamus. Disruptions in circadian rhythms, whether due to genetic mutations, environmental factors, or lifestyle choices, can significantly impact health, contributing to disorders such as sleep disturbances, metabolic syndrome, and cardiovascular diseases.
View Article and Find Full Text PDFThe growing threat of antibiotic-resistant infections demands novel treatment strategies. This study focuses on the transcriptional regulatory protein RfaH, a protein crucial for the bacteria's virulence by promoting gene expression for its capsule, cell wall, and pilus. As becomes resistant to existing antibiotics, targeting RfaH with specific inhibitors offers a promising alternative.
View Article and Find Full Text PDFSci Rep
November 2024
Fungal Induced Calcium Carbonate Precipitation (FICP) is a novel method used in geotechnical engineering that enhances the engineering properties of sand by using the potential of fungal activity. This research is the first attempt to monitor the strength of FICP treated sand using embedded Piezoelectric (PZT) patch based Electromechanical Impedance (EMI) spectroscopy. In the past, the strength of such treated sand has been determined through the destructive methods like Unconfined Compressive Strength (UCS) test.
View Article and Find Full Text PDFMetabolic reprogramming and altered cellular energetics have been recently established as an important cancer hallmark. The modulation of glucose metabolism is one of the important characteristic features of metabolic reprogramming in cancer. It contributes to oncogenic progression by supporting the increased biosynthetic and bio-energetic demands of tumor cells.
View Article and Find Full Text PDFObjective: To investigate the effects of Alogliptin in chemical-induced post-menopausal osteoporosis.
Methodology: The binding affinity of alogliptin with osteogenic proteins was analysed in silico. The effect of alogliptin on osteogenic proteins and mineralization of osteoblastic cells was evaluated in UMR-106 cells.
The current study investigates removing tetracycline from water using batch, column, and tank experiments with statistical modelling using ANN for continuous tests. An artificial neural network (ANN) using the Levenberg-Marquardt back-propagation (LMA) training algorithm is constructed to compare the effectiveness of Tetracycline removal from aqueous solution using the sorption technique with prepared adsorbent. Several characterization analyses XRD, FT-IR, and SEM are employed for prepared Brownmillerite (CaFeO)-Na alginate beads.
View Article and Find Full Text PDFPhytobezoars are solid masses of indigestible plant material and are a common type of gastrointestinal bezoar, with varying incidences globally. These bezoars typically form from the ingestion of high-fiber fruits and vegetables and are associated with factors such as decreased gastric acid production and delayed gastric emptying. We present a case of a 35-year-old healthy man with recurrent upper abdominal pain, nausea, a rolling ball sensation in the abdominal region, and a history of consuming unripe persimmons.
View Article and Find Full Text PDFConsiderable advancements have been made in breast cancer therapeutics in the past few decades. However, the advent of chemo-resistance and adverse drug reactions coupled with tumor metastasis and recurrence posed a serious threat to combat this lethal disease. Novel anti-cancer agents, as well as new therapeutic strategies, are needed to complement conventional breast cancer therapies.
View Article and Find Full Text PDFObjectives: This study aimed to investigate the role of dipeptidyl peptidase-8 and 9 (DPP-8/9) enzymes in inflammatory bone loss using a 4-vinylcyclohexene diepoxide (VCD)-induced model in Wistar rats. Additionally, we evaluated the therapeutic potential of inhibiting these enzymes with the flavonoid chrysin.
Methods: Inflammatory osteoporosis was induced by administering VCD that elevated interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α) levels.
Introduction: Incretin-based therapies have emerged as effective treatments for type 2 diabetes (T2D) and obesity. However, not all patients achieve optimal outcomes with existing treatments, highlighting the need for more effective solutions.
Areas Covered: We present a comprehensive evaluation of Tirzepatide (TZP), a novel dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 (GIP/GLP-1) receptor agonist, for managing obesity and T2D.
Background: The Phosphoinositide 3-kinase (PI3K) inhibitors may be used in cancer progression and mortality along with standard therapy to improve therapeutic efficacy of Advanced Breast Cancer (ABC).
Purpose: This systematic review and meta- analysis were conducted to understand the therapeutic and toxicity profile of PI3K inhibitors in ABC.
Methods: The electronic databases were searched for suitable trials as per the criteria.
Autophagy is a fundamental pillar of cellular resilience, indispensable for maintaining cellular health and vitality. It coordinates the meticulous breakdown of cytoplasmic macromolecules as a guardian of cell metabolism, genomic integrity, and survival. In the complex play of biological warfare, autophagy emerges as a firm defender, bravely confronting various pathogenic, infectious, and cancerous adversaries.
View Article and Find Full Text PDFThe safe ingestion of food and water requires appropriate coordination between the respiratory and swallowing pathways. This coordination can be disrupted because of aging or various diseases, thereby resulting in swallowing disorders. No comparative research has been conducted on methods for effectively screening swallowing disorders in individuals and providing timely alerts to their caregivers.
View Article and Find Full Text PDFMorphine addiction poses a significant challenge to global healthcare. Current opioid substitution therapies, such as buprenorphine, naloxone and methadone are effective but often lead to dependence. Thus, exploring alternative treatments for opioid addiction is crucial.
View Article and Find Full Text PDFCerebral stroke is a pressing global health concern, ranking as the second leading cause of mortality and resulting in persistent neurobehavioral impairments. Cerebral strokes, triggered by various embolic events, initiate complex signaling pathways involving neuroexcitotoxicity, ionic imbalances, inflammation, oxidative stress, acidosis, and mitochondrial dysfunction, leading to programmed cell death. Currently, the FDA has approved tissue plasminogen activator as a relatively benign intervention for cerebral stroke, leaving a significant treatment gap.
View Article and Find Full Text PDFObjective: Evaluating pain in individuals with dementia can be difficult when verbal communication is limited. Vocalization has emerged as a potential avenue for assessments of pain in nonverbal populations. This study aimed to evaluate if physiological assessments of vocalization were correlated with observational assessments of pain during routine blood tests for persons with dementia.
View Article and Find Full Text PDFIntroduction: Identification is an important aspect of forensic medicine. Identification plays an imperative role, especially in highly decomposed bodies, mutilated bodies, and undisclosed and fragmentary human remains. The estimation of sex is an essential parameter of human identification.
View Article and Find Full Text PDFAnkyloglossia, also known as tongue-tie, is a rare congenital anomaly of the oral cavity that not only causes difficulties in breastfeeding and teeth cleaning but also causes difficulty in speech articulation. Our patient faced difficulty in freely moving his tongue because of the short lingual frenulum wherein laser lingual frenectomy was indicated. The patient was treated successfully with a soft tissue diode laser having a wavelength of 445 nanometers.
View Article and Find Full Text PDFJ Family Med Prim Care
February 2024
Introduction: Vitriolage or acid attack or acid throwing is a gender-based terrible violent crime. There are many everlasting sequels of vitriolage which consist of permanent scarring of the face or body, blindness as well as socioeconomic and psychological intricacy. The sufferer of acid attack is competitor, hatred, enmity or jealousy.
View Article and Find Full Text PDFFor centuries, plants have been serving as sources of potential therapeutic agents. In recent years, there has been a growing interest in investigating the effects of plant-derived compounds on epigenetic processes, a novel and captivating Frontier in the field of epigenetics research. Epigenetic changes encompass modifications to DNA, histones, and microRNAs that can influence gene expression.
View Article and Find Full Text PDFPresent investigation includes the magnetizing roasting of low-grade iron ore fines followed by grinding and beneficiation using magnetic separation. The hematite iron ore used in the investigation contains 53.17% T Fe, 10.
View Article and Find Full Text PDFBackground: The "one drug-one target" paradigm has various limitations affecting drug efficacy, such as resistance profiles and adverse effects. Combinational therapies help reduce unexpected off-target effects and accelerate therapeutic efficacy. Sorafenib- an FDA-approved drug for liver cancer, has multiple limitations.
View Article and Find Full Text PDFLectins are non-immunological carbohydrate-binding proteins classified on the basis of their structure, origin, and sugar specificity. The binding specificity of such proteins with the surface glycan moiety determines their activity and clinical applications. Thus, lectins hold great potential as diagnostic and drug discovery agents and as novel biopharmaceutical products.
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