Action Mechanisms of Exosomes Derived from GD3/GD2-Positive Glioma Cells in the Regulation of Phenotypes and Intracellular Signaling: Roles of Integrins.

Extracellular vesicles (EVs) play important roles in intercellular communication in various biological events. In particular, EVs released from cancer cells have attracted special attention. Although it has been reported that cancer-associated glycosphingolipids play important roles in the enhancement of malignant properties of cancer cells, the presence, behavior, and roles of glycosphingolipids in EVs have not been elucidated.

Exploring Through-Space Charge Transfer-Mediated Optoelectrochemical Properties of Dual-State Luminescent Aliphatic Polymers and Optoelectronic Responses toward Metal Ions.

Herein, natural-synthetic hybrid dual-state luminescent conducting polymers (DLCPs/DLCP1-DLCP8) possessing significant optoelectrochemical properties are strategically developed by the polymerization of prop-2-enamide, cis-butenedioic acid, 2-acrylamido-2-methylpropane-1-sulfonic acid, and in situ-generated 2-(3-acrylamidopropanamido)-2-methylpropane-1-sulfonic acid alongside the grafting of gum tragacanth. The spectroscopic data of aliphatic DLCPs affirm DLCP7 as the most stable supramolecular assembly endowing optoelectronic properties. Computational calculations identified -C(═O)NH-, -C(═O)OH, -OH, and -SOH as subluminophores.

Crucial roles of exosomes secreted from ganglioside GD3/GD2-positive glioma cells in enhancement of the malignant phenotypes and signals of GD3/GD2-negative glioma cells.

Neuroectoderm-derived tumors characteristically express gangliosides such as GD3 and GD2. Many studies have reported that gangliosides GD3/GD2 enhance malignant phenotypes of cancers. Recently, we reported that human gliomas expressing GD3/GD2 exhibited enhanced malignant phenotypes.

Synthesis and optimization of chitosan-incorporated semisynthetic polymer/α-FeO nanoparticle hybrid polymer to explore optimal efficacy of fluorescence resonance energy transfer/charge transfer for Co(II) and Ni(II) sensing.

Initially, four synthetic fluorescent polymers (SFPs) are synthesized from α-methacrylic acid and methanolacrylamide monomers carrying -C(=O)OH and -C(=O)NH subfluorophores, respectively. Among SFPs, ∼1:1 incorporation of subfluorophores in the optimum SFP3 is explored by spectroscopic analyses. Subsequently, chitosan is incorporated in SFP3 to produce five semi-synthetic fluorescent polymers (SSFPs).

Ce-Doped TiO Fabricated Glassy Carbon Electrode for Efficient Hydrogen Evolution Reaction in Acidic Medium.

The quest for sustainable and clean energy sources has intensified research on the Hydrogen Evolution Reaction (HER) in recent decades. In this study, we have presented a novel Ce-doped TiO catalyst synthesized through the sol-gel method, showcasing its potential as a superior electrocatalyst for HER in an acidic medium. Comprehensive characterization through X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Energy dispersive X-ray (EDX), and Raman spectroscopy confirms the successful formation of the catalyst.

Validation of the efficiency of arsenic mitigation strategies in southwestern region of Bangladesh and development of a cost-effective adsorbent to mitigate arsenic levels.

World's highest arsenic (As) contamination is well-documented for the groundwater system of southwestern region (mainly Jashore district) of Bangladesh, where the majority of inhabitants are underprivileged. To mitigate As poisoning in southwestern Bangladesh, numerous steps have been taken so far by the government and non-governmental organizations (NGOs). Among them, digging deep tube wells and As removal by naturally deposited Fe(OH) species are being widely practiced in the contaminated areas.

Recent advancements in non-enzymatic electrochemical sensor development for the detection of organophosphorus pesticides in food and environment.

Organophosphorus Pesticides () are among the extensively used pesticides throughout the world to boost agricultural production. However, persistent residues of these toxic pesticides in various vegetables, fruits, and drinking water poses detrimental health effects. Consequently, the rapid monitoring of these harmful chemicals through simple and cost-effective methods has become crucial.

pH dependent electro-oxidation of arsenite on gold surface: Relative kinetics and sensitivity.

A detailed kinetic investigation of As(III) oxidation was performed on gold surface within pH between ∼3.0 and ∼9.0.

Photocatalytic degradation of chlorazol yellow dye under sunlight irradiation using Ce, Bi, and N co-doped TiO photocatalyst in neutral medium.

Chlorazol yellow (CY) is a commonly used anionic, toxic, mutagenic, and potentially carcinogenic azo dye, which is menacing to the environment, aquatic system, food chain, and human health as well. To remove CY dye molecules from an aqueous medium, a series of Ce, Bi, and N co-doped TiO photocatalysts were prepared by varying the composition of the dopants. Under sunlight irradiation, the resultant 5 wt% (Ce-Bi-N) co-doped TiO composite catalyst was found to show the best catalytic activity.

Electrocatalytic reduction of nitrate ions in neutral medium at coinage metal-modified platinum electrodes.

Nitrate is a water-soluble toxic pollutant that needs to be excluded from the environment. For this purpose, several electrochemical studies have been conducted but most of them focused on the nitrate reduction reaction (NRR) in alkaline and acidic media while insignificant research is available in neutral media with Pt electrode. In this work, we explored the effect of three coinage metals (Cu, Ag, and Au) on Pt electrode for the electrochemical reduction of nitrate in neutral solution.

Correlation of antigen-specific immune response with disease severity among COVID-19 patients in Bangladesh.

Coronavirus disease 2019 (COVID-19) is a protean disease causing different degrees of clinical severity including fatality. In addition to humoral immunity, antigen-specific T cells may play a critical role in defining the protective immune response against SARS-CoV-2, the virus that causes this disease. As a part of a longitudinal cohort study in Bangladesh to investigate B and T cell-specific immune responses, we sought to evaluate the activation-induced marker (AIM) and the status of different immune cell subsets during a COVID-19 infection.

Detection of L-Aspartic Acid with Ag-Doped ZnO Nanosheets Using Differential Pulse Voltammetry.

Here, a sensitive voltametric electrochemical sensor probe was fabricated to reliably trace the detection of L-aspartic acid in phosphate-buffered medium using a glassy carbon electrode (GCE) layered with a film of wet-chemically prepared AgO-doped ZnO nanosheets (NSs). EDS, FESEM, XPS, and X-ray diffraction analyses were implemented as characterizing tools of prepared NSs to confirm the structural and compositional morphology, binding energies of existing atoms, and the crystallinity of synthesized NSs. The differential pulse voltammetry (DPV) was applied to the trace detection of L-aspartic acid, and exhibited a wide detection range of 15.

Optimisation and Stability of Rh Particles on Noble Metal Films Immobilised on H Conducting Solid Polymer Electrolyte in Attaining Efficient Nitrate Removal.

During the electrocatalytic reduction of nitrate, nitrite is often evolved as a product along with ammonia due to the sluggish nitrite-to-ammonia conversion process compared to the nitrate-to-nitrite conversion step. Rhodium metal has been proven to enhance nitrite-to-ammonia conversion rates, yielding ammonia as the only final product. In the present article, we have shown how effectively Rh nanoparticles immobilized on Pt and Pd films deposited on H conducting Nafion-117 membranes eliminate intermediate nitrite ions during the progress of the nitrate reduction reaction in a flow type reactor.

Metal-Organic Frameworks Derived Electrocatalysts for Oxygen and Carbon Dioxide Reduction Reaction.

The increasing demands of energy and environmental concerns have motivated researchers to cultivate renewable energy resources for replacing conventional fossil fuels. The modern energy conversion and storage devices required high efficient and stable electrocatalysts to fulfil the market demands. In previous years, we are witness for considerable developments of scientific attention in Metal-organic Frameworks (MOFs) and their derived nanomaterials in electrocatalysis.

Disease characteristics and serological responses in patients with differing severity of COVID-19 infection: A longitudinal cohort study in Dhaka, Bangladesh.

Background: COVID-19 caused by SARS-CoV-2 ranges from asymptomatic to severe disease and can cause fatal and devastating outcome in many cases. In this study, we have compared the clinical, biochemical and immunological parameters across the different disease spectrum of COVID-19 in Bangladeshi patients.

Methodology/principal Findings: This longitudinal study was conducted in two COVID-19 hospitals and also around the community in Dhaka city in Bangladesh between November 2020 to March 2021.

A five-day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness.

Ivermectin, a US Food and Drug Administration-approved anti-parasitic agent, was found to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in vitro. A randomized, double-blind, placebo-controlled trial was conducted to determine the rapidity of viral clearance and safety of ivermectin among adult SARS-CoV-2 patients. The trial included 72 hospitalized patients in Dhaka, Bangladesh, who were assigned to one of three groups: oral ivermectin alone (12 mg once daily for 5 days), oral ivermectin in combination with doxycycline (12 mg ivermectin single dose and 200 mg doxycycline on day 1, followed by 100 mg every 12 h for the next 4 days), and a placebo control group.

Heterogeneous Kinetics of Thiourea Electro-Catalytic Oxidation Reactions on Palladium Surface in Aqueous Medium.

The electrochemical behaviors of thiourea (TU) oxidation have been studied at Palladium (Pd) electrode in the acidic medium by recording cyclic voltammograms (CVs). The influence of pH was investigated in the pH range of 1.0 to 9.

Electrocatalytic Oxidation of 4-Aminophenol Molecules at the Surface of an FeS /Carbon Nanotube Modified Glassy Carbon Electrode in Aqueous Medium.

FeS /carbon nanotube (CNT) nanocomposites were synthesized and immobilized on the surface of a glassy carbon electrode (GCE) in order to investigate the electrocatalytic conversion of 4-aminophenol (4-AP) into p-quinone in an aqueous medium. The reformed electronic properties (in terms of lowering of band-gap energy and charge-transfer resistance), as well as improved surface area, result in an enhanced redox reaction of 4-AP in the presence of FeS -CNT NCs compared to that with FeS alone. The 4-AP molecules undergo coupled two-proton and two-electron transfer quasi-reversible redox reactions with a symmetry factor of 0.