Publications by authors named "Mohammad A Alobaidy"
Enhanced hepatoprotective effects of empagliflozin and vitamin D dual therapy against metabolic dysfunction-associated steatohepatitis in mice by boosted modulation of metabolic, oxidative stress, and inflammatory pathways.
Int J Exp Pathol
December 2024
Article Synopsis
- The study investigates the combined effects of sodium-glucose cotransporter-2 inhibitors (SGLT2i) and vitamin D (VD) on metabolic dysfunction-associated steatohepatitis (MASH) in type 2 diabetic mice, filling a gap in previous research.
- Diabetic mice were subjected to a high-fructose/high-fat diet and then treated with either SGLT2i, VD, or both, revealing that while SGLT2i alone was effective, the combination treatment offered superior protection.
- Results showed significant improvements in metabolic parameters, liver health, and reductions in inflammation and oxidative stress markers, indicating that the combined therapy enhances hepatic protection against diabetes-induced MASH.
Herein, we measured the antidiabetic and nephroprotective effects of the sodium-glucose cotransporter-2 inhibitor (empagliflozin; SGLT2i) and synthetic active vitamin D (paricalcitol; Pcal) mono- and co-therapy against diabetic nephropathy (DN). Fifty mice were assigned into negative (NC) and positive (PC) control, SGLT2i, Pcal, and SGLT2i+Pcal groups. Following establishment of DN, SGLT2i (5.
View Article and Find Full Text PDFPurpose: To understand the geometry of the proximal humerus and glenoid fossa to facilitate the design of components used in shoulder arthroplasty. The aim is to evaluate the geometry of the proximal humerus and glenoid fossa and their relationship using a MicroScribe 3D digitizer.
Methods: Scans and measurements were obtained from 20 pairs of dry proximal humeri and scapulae [10 female and 10 male cadavers: median age 81 years (range 70-94 years)] using a MicroScribe 3D digitizer and Rhinoceros software.
Background: Understanding the geometry of the coracoid and coracoacromial arch will improve surgical intervention in shoulder surgery.
Methods: Thirty pairs of scapulae from 20 female and 10 male deceased donors, average age of 82 years (range, 62-101 years), were scanned and measurements taken using the 3-dimensional (3D) MicroScribe digitizer (Immersion Corp, San Jose CA, USA) and Rhino software (McNeel North America, Seattle, WA, USA).
Results: The following mean angles were determined: coracoid slope, 44° ± 11°; coracoid deviation, 35° ± 6°; coracoid root to glenoid, 115° ± 14°; coracoid head to glenoid, 110° ± 11°; scapular spine angle, 35° ± 6°; and coracoacromial angle, 63° ± 9°.