Publications by authors named "Mohamed-Assem Said Marie"
Multidrug resistance (MDR) is a critical hindrance to the success of cancer chemotherapy. The main thing responsible for MDR phenotypes are plasma-membranes associated with adenosine triphosphate (ATP) Binding Cassette (ABC) drug efflux transporters, such as the P-glycoprotein (Pgp) transporter that has the broadest spectrum of substrates. Curcumin (CURC) is a Pgp inhibitor, but it is poorly soluble and bioavailable.
View Article and Find Full Text PDFBackground: Diabetes mellitus is the main reason of morbidity and mortality worldwide. In recent years great attention has been paid to bioactivity of natural products due to their potential pharmacological utilization. Echinochrome is a natural compound isolated from sea urchins and possesses many biological effects.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the anti-diabetic effects of echinochrome, a pigment from sea urchins, on diabetic rats, distinguishing between type 1 and type 2 diabetes models induced by streptozotocin and a high-fat diet.
- - Rats treated with echinochrome showed lower blood glucose and harmful metabolic markers while exhibiting increased insulin levels and improvements in antioxidant enzyme activities over a four-week period.
- - The research indicates that echinochrome may reduce complications from diabetes in the liver through both lowering blood sugar and providing antioxidant benefits, along with a positive impact on pancreatic and liver tissue health.