Publications by authors named "Mohamed Wahid"
Article Synopsis
- * MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression and are being explored as biomarkers and treatment targets for early detection and intervention in BC.
- * The review highlights how dysregulated miRNA expression affects cellular metabolism in BC, showing their potential role in targeting key metabolic pathways and pushing for future clinical applications as diagnostic and therapeutic tools.
Article Synopsis
- KEYNOTE-394 trial found that pembrolizumab significantly improved survival rates and quality of life for Asian patients with advanced liver cancer compared to a placebo.
- Health-related quality of life was assessed using two questionnaires, revealing that patients on pembrolizumab experienced less decline in their quality of life scores versus those on placebo at 12 weeks.
- The study concludes that pembrolizumab offers a meaningful benefit with acceptable safety for patients in need of second-line treatment for advanced hepatocellular carcinoma.
Objective: Multimodal intraoperative neuromonitoring (IOM) using somatosensory-evoked potentials and motor-evoked potentials is a sensitive and specific tool for detecting intraoperative neurologic injury during spine surgery. This study aimed to evaluate the use of multimodal IOM in a lower-middle-income country (LMIC) during cervical and thoracic spine surgery in order to prevent and predict new postoperative neurologic deficits early on. This is the first report of multimodal IOM application in LMICs.
View Article and Find Full Text PDFPurpose: This descriptive cross-sectional survey aims to assess the level of concordance between the perspectives of oncologists and those of patients regarding oral mucositis (OM) symptoms, and the impact of OM on various aspects of daily living and concurrent cancer management.
Methods: Oncologists involved in OM management (n = 105), and patients who developed OM during cancer treatment (n = 175), were recruited from seven Asian countries. Oncologists completed a face-to-face, quantitative interview; patients completed a face-to-face interview, and a self-reported questionnaire.
Background: Brain metastases occur in about 20-40% of patients with non-small-cell lung carcinoma (NSCLC), and are usually associated with a poor outcome. Whole brain radiotherapy (WBRT) is widely used but increasingly, more aggressive local treatments such as surgery or stereotactic radiosurgery (SRS) or stereotactic radiotherapy (SRT) are being employed. In our study we aimed to describe the various factors affecting outcomes in NSCLC patients receiving local therapy for brain metastases.
View Article and Find Full Text PDFIntroduction: Despite available data from other Asian countries, the prevalence of epidermal growth factor receptor (EGFR) mutations among lung adenocarcinoma patients has not been reported in Malaysia. This study sought to determine the frequency of EGFR mutations among multiethnic Malaysian patients diagnosed with lung adenocarcinoma.
Methods: Demographic and clinical information of patients whose lung adenocarcinoma biopsy specimens were submitted for EGFR mutation testing at Sime Darby Medical Center from 2009 to 2011 were analyzed.
Effects of fasting during ramadan month on cognitive function in muslim athletes.
Asian J Sports Med
September 2011
Purpose: Our study aimed to profile the effect of fasting during the Ramadan month on cognitive function in a group of healthy Muslim athletes.
Methods: Eighteen male athletes underwent computerized neuropsychological testing during (fasting) and after (non-fasting) Ramadan. Diet was standardized, and tests were performed at 0900h and 1600h to characterize potential time-of-day (TOD) interactions.
Kidney Cancer Working Group report.
Jpn J Clin Oncol
September 2010
Unlabelled: Kidney cancer accounts for approximately 2% of all cancers worldwide, with renal cell carcinoma being the most common form and this report is focused on renal cell carcinoma. Globally, the incidence and mortality rates are increasing by 2-3% per decade. Kidney cancer is less common in Asia compared with the West.
View Article and Find Full Text PDFObjective: This study examines the effects of Ramadan fasting on endurance performance.
Method: Using a crossover design, 10 moderately trained, active Muslim men performed 60 min runs on a treadmill in the fasted (Ramadan, RAM) and non-fasted (Control, CON) state on two separate counterbalanced occasions. After familiarization, four subjects performed their CON trial 1 week before Ramadan, while the other six subjects performed their CON trial 1 week after the Ramadan month.