Two-Stage Voice Application Recommender System for Unhandled Utterances in Intelligent Personal Assistant.

Intelligent personal assistants (IPA) enable voice applications that facilitate people's daily tasks. However, due to the complexity and ambiguity of voice requests, some requests may not be handled properly by the standard natural language understanding (NLU) component. In such cases, a simple reply like "Sorry, I don't know" hurts the user's experience and limits the functionality of IPA.

FROST: Fallback Voice Apps Recommendation for Unhandled Voice Commands in Intelligent Personal Assistants.

Intelligent personal assistants (IPAs) such as Amazon Alexa, Google Assistant and Apple Siri extend their built-in capabilities by supporting voice apps developed by third-party developers. Sometimes the smart assistant is not able to successfully respond to user voice commands (aka utterances). There are many reasons including automatic speech recognition (ASR) error, natural language understanding (NLU) error, routing utterances to an irrelevant voice app, or simply that the user is asking for a capability that is not supported yet.

Schizophrenia interactome with 504 novel protein-protein interactions.

Genome-wide association studies of schizophrenia (GWAS) have revealed the role of rare and common genetic variants, but the functional effects of the risk variants remain to be understood. Protein interactome-based studies can facilitate the study of molecular mechanisms by which the risk genes relate to schizophrenia (SZ) genesis, but protein-protein interactions (PPIs) are unknown for many of the liability genes. We developed a computational model to discover PPIs, which is found to be highly accurate according to computational evaluations and experimental validations of selected PPIs.

An efficient heuristic method for active feature acquisition and its application to protein-protein interaction prediction.

Background: Machine learning approaches for classification learn the pattern of the feature space of different classes, or learn a boundary that separates the feature space into different classes. The features of the data instances are usually available, and it is only the class-labels of the instances that are unavailable. For example, to classify text documents into different topic categories, the words in the documents are features and they are readily available, whereas the topic is what is predicted.

Suite of tools for statistical N-gram language modeling for pattern mining in whole genome sequences.

Genome sequences contain a number of patterns that have biomedical significance. Repetitive sequences of various kinds are a primary component of most of the genomic sequence patterns. We extended the suffix-array based Biological Language Modeling Toolkit to compute n-gram frequencies as well as n-gram language-model based perplexity in windows over the whole genome sequence to find biologically relevant patterns.

Active learning for human protein-protein interaction prediction.

Background: Biological processes in cells are carried out by means of protein-protein interactions. Determining whether a pair of proteins interacts by wet-lab experiments is resource-intensive; only about 38,000 interactions, out of a few hundred thousand expected interactions, are known today. Active machine learning can guide the selection of pairs of proteins for future experimental characterization in order to accelerate accurate prediction of the human protein interactome.