Prognostic Implication of MIF Gene Expression in Childhood Acute Lymphoblastic Leukemia.

Background: Cytogenetic and molecular genetic markers have been used recently to stratify risk and predict prognosis of different types of cancers. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that plays an important role in the pathogenesis of many diseases, such as autoimmune diseases and cancers. We studied MIF gene expression behavior to investigate its prognostic impact in childish patients with acute lymphoblastic leukemia (ALL).

MIF-173G/C (rs755622) polymorphism as a risk factor for acute lymphoblastic leukemia development in children.

Background: Macrophage inhibitory factor (MIF) is a pro-inflammatory cytokine modulating monocyte motility and a pleiotropic regulator of different biological and cellular processes. The MIF-173G/C (rs755622) polymorphism is found in the promoter region and affects its activity. The present study investigated the MIF polymorphism as a risk factor for the development of acute lymphoblastic leukemia (ALL) in Egyptian children.

Prognostic implication of BAALC gene expression in adult acute myeloid leukemia.

Background: Recently various molecular markers and global gene expression profiling have been investigated to improve risk profile characterization of AML with normal cytogenetics. Our main objective is to investigate the prognostic impact of brain and acute leukemia, cytoplasmic (BAALC) expression in AML with normal karyotype.

Methods: BAALC expression was analysed using quantitative real time (QRT) PCR.