Publications by authors named "Mohamed Shaad Hasim"
Article Synopsis
- Type 1 innate lymphoid cells (ILC1) play a crucial role in defending against infections and exhibit different states of functionality in various conditions.
- Research shows that ILC1 in the liver are diverse, particularly in their expression of effector molecules like granzyme A (GzmA) and surface receptors like CD160, with those expressing high GzmA being more prevalent as mice age.
- The study also finds that ILC1 are distinct from natural killer (NK) cells and that their diversity may arise from the ability of ILC3 cells to transform into ILC1, contributing to various functions such as cytotoxicity and IFN-γ production.
One of the hallmarks of Alzheimer's disease (AD) is the accumulation and deposition of amyloid-β (Aβ) peptides in the brain and cerebral vasculature. Aβ evokes neuroinflammation and has been implicated in insulin signaling disruption and JNK-AP1 activation, contributing to AD neuropathologies including oxidative injury and vascular insufficiencies. In this study we aim to better understand the protective mechanisms of insulin signaling and JNK-AP1 inhibition on the adverse effects of Aβ.
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