Publications by authors named "Mohamed Sami Mourali"
Unlabelled: BACKGROUND AND OBJECTIVE: Left atrial strain (LAS) has prognostic value in patients with atrial fibrillation (AF). Consequently, therapies that improve LAS may help reduce AF-related adverse cardiac events. We aimed to compare how digoxin and bisoprolol modulate LAS in patients with AF being treated with rate control.
View Article and Find Full Text PDFBackground: In Tunisia, the number of cardiac implantable electronic devices (CIEDs) is increasing, owing to the increase in patient life expectancy and expanding indications. Despite their life-saving potential and a significant reduction in population morbidity and mortality, their increased numbers have been associated with the development of multiple early and late complications related to vascular access, pockets, leads, or patient characteristics.
Objective: The study aims to identify the rate, type, and predictors of complications occurring within the first year after CIED implantation.
Background: This study was designed to evaluate the care of hypertensive patients in daily clinical practice in public and private centers in all Tunisian regions.
Objective: This study will provide us an overview of hypertension (HTN) management in Tunisia and the degree of adherence of practitioners to international recommendations.
Methods: This is a national observational cross-sectional multicenter study that will include patients older than 18 years with HTN for a duration of 4 weeks, managed in the public sector from primary and secondary care centers as well as patients managed in the private sector.
Background: Matrix metalloproteinases (MMPs) are widely expressed in atherosclerosis lesions. The disequilibrium of MMPs driving to an overexpression or a lack of its level can be influenced by genetic variations. MMP-3 and MMP-9 may be affected by specific polymorphisms like - 1612 5 A/6A and the - 1562 C/T respectively.
View Article and Find Full Text PDFBackground: Coronary artery diseases remain the leading cause of death in the world. The management of this condition has improved remarkably in the recent years owing to the development of new technical tools and multicentric registries.
Objective: The aim of this study is to investigate the in-hospital and 1-year clinical outcomes of patients treated with percutaneous coronary intervention (PCI) in Tunisia.
Introduction: New-onset AF atrial fibrillation (NOAF) frequently complicates acute coronary syndromes (ACS) leading to adverse outcomes in the short and long term. The prevalence of NOAF in patients hospitalized for ACS is variably reported and ranges between 2 and 37%. Several predictor factors have been implicated in the literature but remain a subject of controversy.
View Article and Find Full Text PDFBackground: Hypertension is the leading cause of morbi-mortality in our country. Thus, we conducted this national survey on hypertension to analyze the profile of the Tunisian hypertensive patient and to assess the level of blood pressure control.
Methods: Nature HTN is an observational multicentric survey, including hypertensive individuals and consulting their doctors during the period of the study.
Article Synopsis
- The prevalence of heart failure (HF) is increasing in Tunisia, largely due to an aging population and rising rates of coronary artery disease and hypertension, yet there's limited data on patient demographics and care quality.
- The study aims to create the National Tunisian Registry of Heart Failure (NATURE-HF) by analyzing and following 1700 patients over a year, with assessments at 1, 3, and 12 months.
- Results will include tracking cardiovascular and overall mortality, hospital readmissions, and various clinical evaluations and treatment outcomes to gain insights into the management of HF in Tunisia.
Background: This study investigated the association of angiotensin-converting enzyme (ACE I/D) and aldosterone synthase (CYP11B2-344C/T) gene polymorphisms in the renin-angiotensin-aldosterone system (RAAS) with atrial fibrillation (AF) in the Tunisian population.
Materials And Methods: The study population included 120 patients with AF and 123 age-matched controls. Genotyping of the I/D polymorphism in the ACE gene and the -344C/T polymorphism in the CYP11B2 gene was performed by polymerase chain reaction (PCR) and PCR-RFLP methods, respectively.
Article Synopsis
- * The study included 915 patients, primarily middle-aged, where about 22.4% were found to have valvular AF, and only half of the patients with low embolic risk were prescribed oral anticoagulants.
- * Findings highlighted that the management strategies for AF in Tunisia were inadequate, with concerns over low anticoagulation quality, as evidenced by a 1.64% thromboembolism rate and a notable number of patients not receiving proper antithrom
Article Synopsis
- OSAS is highly prevalent in patients with non-valvular atrial fibrillation (NVAF), with a detection rate of 90% among those studied.
- The study determined that OSAS severity was categorized as mild in 32%, moderate in 27%, and severe in 31% of NVAF patients.
- Independent predictors for OSAS included being over 61 years old, having AF for more than 2 years, and snoring.
Background: Silent strokes are damagesof brain not accompanied by symptoms suggestive of stroke. Currentepidemiological trends suggesttheirindependent association with atrial fibrillation (AF). However, this association is not yetwelldefined.
View Article and Find Full Text PDFEvaluation of electrocardiographic findings before and after hemodialysis session.
Saudi J Kidney Dis Transpl
June 2021
Dialysis patients have higher rates of sudden cardiac death. The study of the electrocardiogram could identify patients at risk of developing rhythm disorders. The aim of this study was to evaluate the electrocardiographic findings before and after the hemodialysis (HD) session and to examine associations of clinical and serum electrolytes with electrocardiogram findings.
View Article and Find Full Text PDFWe report the case of a 23-year-old woman with a not yet described (to the best of our knowledge) association of left ventricle non-compaction with both atrial and ventricular defects. Family genetic survey concluded to, a probably sporadic, E101K gene mutation.
View Article and Find Full Text PDFBackground: Cardiac arrest (CA) is a public health problem, with various etiologies and a fatal issue in 90-95% of cases. Toxin-induced cardiac arrests (TICA) are poorly described. Scarcity of national data prompted us to carry-out this study.
View Article and Find Full Text PDFArticle Synopsis
- - Nurses in cardiac intensive care units are crucial for managing cardiac arrests and often participate in hands-on resuscitation efforts.
- - A study evaluated the effectiveness of simulation training on improving the skills of nurses, finding a significant increase in competency scores after training.
- - The training notably enhanced skills in basic life support and manual defibrillation, with the most improvement seen in areas where nurses had less prior experience.
Article Synopsis
- The study investigates the role of strain in diagnosing and predicting outcomes in non-ST elevation myocardial infarction (NSTEMI) patients, focusing on its relationship with disease severity and coronary artery blockages.
- The research included 70 NSTEMI patients, revealing that global longitudinal strain (GLS) effectively predicted reduced left ventricular ejection fraction (LVEF) and indicated severe coronary artery disease (CAD), while territorial longitudinal strain (TLS) accurately identified the responsible artery and potential occlusions.
- Follow-up results showed that GLS improved over time, with factors like initial LVEF and myocardial revascularization contributing to this positive change, highlighting the significance of strain measurements in NSTEMI management.
Article Synopsis
- In the acute phase of STEMI, traditional viability imaging is either not validated or unavailable, prompting an evaluation of strain parameters as predictive tools for post-revascularization myocardial viability.
- A study involving 31 STEMI patients used echocardiograms to measure global longitudinal strain (GLS) and territorial longitudinal strain (TLS) within 24 hours of admission, later correlating these findings with delayed enhancement cardiac magnetic resonance imaging (CMR) performed three months after treatment.
- The results indicated that lower GLS and TLS values were associated with nonviable myocardium, with specific threshold values predicting viability with good sensitivity and specificity, suggesting that these strain measurements could help prioritize coronary interventions in STEMI patients.
Background: Multiple arterial coronary artery bypass grafting is a controversial surgical procedure that is still uncommon worldwide. The aim of our study was to determine the outcomes and perioperative complications of the multiple arterial myocardial revascularization and their predictive factors, the mid-term and long term clinical and angiographic prognosis of the studied patients.
Methods: This was a single center study of the cardiovascular department of The Rabta hospital.
The acute ischemia of the lower limb on the veno-arterial Extracorporeal Membrane Oxygenation (ECMO) is a frequent and dangerous complication that can put the vital and functional prognosis at risk. Several risk factors have been incriminated and the lack of a sufficient distal perfusion is the most common. We report the case of an 11-year-old girl with veno-arterial ECMO for acute myocarditis complicated by severe acute lower limb ischemia.
View Article and Find Full Text PDFIntroduction: Atrial septal defects (ASD) constitute the most frequent congenital heart disease in adults and ostium secundum (OS) the most common type. Benefit of its closure in adulthood has long been controversial.
Aim: To evaluate outcomes of OS-ASD closure in adults.
Background: The continuing increase in care, needs and costs in cardiology with the advances in percutaneous coronary intervention (PCI) techniques represent the ideal scenario for considering same-day discharge (SDD) PCI program.
Aim: The primary endpoints were to examine feasibility and safety of SDD-PCI.
Methods: We conducted a comparative observational study of a prospective cohort (April 2017 to September 2017) where patients benefited from SDD-PCI with a retrospective cohort (October 2016 to March 2017) where patients were conventionally managed.
Background: Cardiogenic shock complicating ST elevation myocardial infarction is burdened by a high mortality. There is only limited evidence for the management except for early revascularization and the relative ineffectiveness of intra-aortic balloon pump.
Aim: Our objectives were to evaluate outcome and predictors of early all-cause 30-day mortality in the setting of cardiogenic shock complicating ST elevation myocardial infarction.
Background: Unprotected left main (LM) coronary artery disease (CAD) represents a challenging lesion with a major prognostic impact.
Aim: Evaluate the clinical outcome and major adverse cardiac events (MACE) predictors of unprotected LM percutaneous coronary intervention (PCI) in an "all-comers" population.
Methods: We performed a prospective observational study of patients with unprotected LM stenosis treated by PCI.