Publications by authors named "Mohamed Sadek Almiski"
Article Synopsis
- Dendritic cells (DCs) significantly influence allergic asthma, and the absence of Sema3E worsens asthma symptoms in experimental models.
- This study focuses on PlexinD1 in CD11c+ DCs using a house dust mite model, comparing PlexinD1 knockout mice (CD11cPLXND1 KO) with wild-type controls (PLXND1fl/fl).
- Results show that CD11cPLXND1 KO mice had increased airway hyperresponsiveness, mucus production, and immune response, indicating that PlexinD1 plays a crucial role in regulating asthma features through DC signaling.
