Publications by authors named "Mohamed S Almiski"
Article Synopsis
- Dendritic cells (DCs) significantly influence allergic asthma, and the absence of Sema3E worsens asthma symptoms in experimental models.
- This study focuses on PlexinD1 in CD11c+ DCs using a house dust mite model, comparing PlexinD1 knockout mice (CD11cPLXND1 KO) with wild-type controls (PLXND1fl/fl).
- Results show that CD11cPLXND1 KO mice had increased airway hyperresponsiveness, mucus production, and immune response, indicating that PlexinD1 plays a crucial role in regulating asthma features through DC signaling.
Interstitial macrophages (IMs) are key regulators of allergic inflammation. We previously showed that the absence of semaphorin 3E (Sema3E) exacerbates asthma features in both acute and chronic asthma models. However, it has not been studied whether Sema3E, via its receptor plexinD1, regulates IM function in allergic asthma.
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