Publications by authors named "Mohamed S Abdool-Gaffar"
Idiopathic pulmonary fibrosis (IPF) is a very specific form of a chronic, progressive fibroproliferative interstitial pneumonia of unknown aetiology. The disease is generally associated with a poor prognosis. Several international evidence-based guidelines on the diagnosis and management of IPF and other interstitial lung diseases (ILDs) have been published and updated in the last decade, and while the body of evidence for the use of some treatment modalities has grown, others have been shown to be futile and even harmful to patients.
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- - The study aimed to assess whether combining nicotine replacement therapy (NRT) with varenicline is more effective and safe for quitting smoking than using varenicline alone.
- - Conducted as a randomized, blinded clinical trial with 446 smokers in South Africa over a 12-week treatment period, the trial measured tobacco abstinence through exhaled carbon monoxide levels.
- - Results showed that the combination treatment led to significantly higher rates of continuous abstinence at both 12 weeks (55.4% vs. 40.9%) and 24 weeks (49.0% vs. 32.6%) compared to varenicline alone.