A novel approach for simulating and optimizing the production costing system.

This paper presents a novel approach for simulating and optimizing production costing systems using linear programming. The proposed method employs a linear programming algorithm to simulate the behavior of production costs and to derive optimal solutions, including cost minimization, resource maximization, and economic returns. This approach has been implemented as a standard platform computer application, which automatically processes the costing system to reflect real-world behavior accurately.

Is there a potential dual effect of denosumab for treatment of osteoporosis and sarcopenia?

Background: The prevalence of sarcopenia with osteoporosis results in a higher risk of falling and fractures. It was noted that patients who had completed their planned 5-year denosumab therapy course as treatment for these conditions started to sustain falls.

Purpose: To assess (a) whether denosumab has a unique dual effect on both bone and muscle in comparison to other anti-resorptive agents and (b) its effectiveness in the follow-up period post-treatment completion compared to other anti-resorptive agents.

Preprocessing Arabic text on social media.

urrently, social media plays an important role in daily life and routine. Millions of people use social media for different purposes. Large amounts of data flow through online networks every second, and these data contain valuable information that can be extracted if the data are properly processed and analyzed.

Long term oral anticoagulant therapy with warfarin: experience with local patient population in kuwait.

Warfarin (Coumadin) continues to remain the mainstay of oral anticoagulant therapy (OACT) for thromboprophylaxis for both venous thromboembolic disease (VTD) and cardiac indications. However it needs careful monitoring because of its narrow window of target activity level, interaction with numerous medications and food items, caution for use in patients with co-morbidities like hepatic and renal impairment and bleeding lesions and the risk of major hemorrhage. A large part of its success and safety requires the patients own understanding and participation in its control.

Effective control of polymyalgia rheumatica with tocilizumab.

Despite their disadvantages, glucocorticoids (GCs) remain a mainstay of therapy for polymyalgia rheumatica (PMR). Second-line antirheumatic and immune-modulatory drugs are not infrequently required because of disease relapses during GC tapering and GC adverse effects. Therapy with methotrexate or with an anti-tumor necrosis factor drug showed modest efficacy in this situation.

Central pontine myelinolysis in the hyperosmolar hyperglycaemic state.

Objective: To report a rare association of central pontine myelinolysis (CPM) with hyperosmolar hyperglycaemic state (HHS).

Clinical Presentation And Intervention: A diabetic female presented with HHS and prolonged severe hypernatraemia. The metabolic derangement was adequately treated with proper correction of both hyperglycaemia and hypernatraemia.

Atypical clinical manifestations of graves' disease: an analysis in depth.

Over the past few decades, there has been an increase in the number of reports about newly recognized (atypical or unusual) manifestations of Graves' disease (GD), that are related to various body systems. One of these manifestations is sometimes the main presenting feature of GD. Some of the atypical manifestations are specifically related to GD, while others are also similarly seen in patients with other forms of hyperthyroidism.

Hypothermia with pneumonia: a rare presentation of brucellosis.

Objective: To report a very rare form of brucellosis presenting with hypothermia and pneumonia.

Clinical Presentation And Intervention: A 41-year-old male shepherd presented with a depressed level of consciousness. Clinically, his rectal temperature was 29.

Anticoagulation for cerebral venous thrombosis with subarachnoid hemorrhage: a case report.

Objectives: To report the success of anticoagulation (AC) treatment in a case of cerebral venous thrombosis (CVT) with subarachnoid hemorrhage (SAH) in view of the limited evidence seen in the literature supporting such a treatment option.

Clinical Presentation And Intervention: A 38-year-old lady with CVT and SAH presented 12 h after the onset of symptoms. AC with low-molecular-weight heparin was started 4 days later, when the repeated brain CT showed regression of the SAH.

Lymphocytic enterocolitis in systemic lupus erythematosus.

Microscopic colitis (MC) is a recognized cause of chronic watery diarrhea. It is characterized by subepithelial collagen deposition or intraepithelial lymphocytic infiltration of the colonic mucosa which, however, appears grossly normal on endoscopy. The term microscopic enterocolitis is applied when MC is associated with similar microscopic affection of the ileum and/or proximal small intestine.

Pulmonary hypertension responding to hyperthyroidism treatment.

Pulmonary hypertension in adults with hyperthyroidism is increasingly being reported. Although the mechanism is uncertain, the reversal of pulmonary hypertension following restoration to an euthyroid state supports a causal relationship. This case report is of a 43-year-old woman who presented with Graves disease and right ventricular failure.