Publications by authors named "Mohamed Nouhoum"
Article Synopsis
- The study tackled the difficult task of imaging the trigeminal ganglion (TG), a small and deep-seated structure, by combining advanced imaging techniques to analyze blood flow and respond to orofacial stimuli in rats.
- Functional ultrasound imaging successfully captured strong hemodynamic responses in the TG, linked to various mechanical and chemical stimulations of nociceptive fibers in the face, highlighting the area’s sensitivity despite the limited number of sensory neurons.
- This innovative imaging method not only visualized the vasculature of the TG but also offers new insights for understanding the mechanisms of trigeminal pain, paving the way for future research in treatment options.
Functional ultrasound (fUS) imaging is a novel brain imaging modality that relies on the high-sensitivity measure of the cerebral blood volume achieved by ultrafast doppler angiography. As brain perfusion is strongly linked to local neuronal activity, this technique allows the whole-brain 3D mapping of task-induced regional activation as well as resting-state functional connectivity, non-invasively, with unmatched spatio-temporal resolution and operational simplicity. In comparison with fMRI (functional magnetic resonance imaging), a main advantage of fUS imaging consists in enabling a complete compatibility with awake and behaving animal experiments.
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