Toxoplasma gondii Suppresses Th2-Induced by Infection and Downregulates Serine Protease Genes Expression: A Critical Role in Vaccine Development.

Background: coinfection can modify host immune responses and the severity and spread of other parasites. We investigated how and infections counter-regulate each other's immune responses.

Methods: The parasite burden, the expression of rhoptry kinase ROP18 and putative serine protease (TsSP), the IgG1 and IgG2a responses, besides histopathological and immunohistochemical staining with iNOS and arginase were used to evaluate the dynamics of coinfection.

Influence of some methylated hepatocarcinogenesis-related genes on the response to antiviral therapy and development of fibrosis in chronic hepatitis C patients.

Epigenetics involved in multiple normal cellular processes. Previous research have revealed the role of hepatitis C virus infection in accelerating methylation process and affecting response to treatment in chronic hepatitis patients. This work aimed to elucidate the role of promoter methylation (PM) in response to antiviral therapy, and its contribution to the development of fibrosis through hepatocarcinogenesis-related genes.