Publications by authors named "Mohamed Mihoubi"
The wide variety of potent biological activities of Morita-Baylis-Hillman adducts (MBH) encouraged us to synthesize new series of products belonging to this class of compounds, possessing different functionalities and exhibiting potential antioxidant activity. As part of our on-going program on targeting molecules with antioxidant activity, we describe herein different DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging activities of MBH alcohols and their derivatives including acetates, phosphonates and hydrazonophosphonates. The obtained results showed that the strongest DPPH radical scavenging activity was observed in the case of hydrazonophosphonates in comparison to the other MBH derivatives.
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- The natural alkaloid N-methylisosalsoline, extracted from Hammada scoparia leaves, shows promising activity against the human 20S proteasome, indicating its potential as a basis for new anticancer drugs.
- A new series of isosalsoline-type alkaloids were synthesized, featuring variations at specific positions, achieved through a method called Bischler-Napieralski cyclization.
- The process included an innovative double reduction of nitroalkene to create the necessary substrate for building complex tetrahydroisoquinoline structures.