Publications by authors named "Mohamed Maiga"
Article Synopsis
- The study investigates the effects of cabamiquine and pyronaridine on the P. falciparum malaria parasite, looking at their performance as standalone treatments and in combination therapy.
- Using field isolates and a pharmacometrics model, researchers create an interaction map to simulate effective clinical dose ratios for these antimalarials.
- Results indicate that while pyronaridine alone is less effective, the combination of cabamiquine and pyronaridine significantly improves parasite killing, suggesting the methodology can aid in developing new malaria treatments.
Imidazolopiperazine (IPZ), KAF156, a close analogue of GNF179, is a promising antimalarial candidate. IPZ is effective against and clinical malaria in human with transmission blocking property in animal models and effective against liver stage parasites. Despite these excellent drug efficacy properties, in vitro parasites have shown resistance to IPZ.
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- Scientists studied how a medicine called cabamiquine, which fights malaria, might lead to some parasites becoming resistant to it.
- They found 11 specific changes in the parasites that made them resistant, and 6 of these changes were seen in more than one type of study.
- The researchers also used math to show that some resistant parasites might have already existed before the medicine was given, suggesting the experiments could vary a lot based on how they were set up.
Article Synopsis
- Malaria elimination is hindered by Plasmodium vivax due to its persistent hypnozoite form in the liver, which leads to relapsing infections and complicates transmission interruption, especially in Duffy-positive individuals traditionally found outside Africa.
- Recent studies using molecular techniques have identified P. vivax in Duffy-negative people in various African countries, highlighting a gap in research focus primarily on falciparum malaria and limited lab infrastructure for studying P. vivax.
- Field transmission of Ethiopian P. vivax was established for research in Mali, revealing that while tafenoquine effectively inhibits hypnozoite and schizont forms, atovaquone and KDU691 have no effect on hypnozoites but are
Microarray technology is widely used for gene expression research targeting the development of new drug treatments. In the case of a two-color microarray, the process starts with labeling DNA samples with fluorescent markers (cyanine 635 or Cy5 and cyanine 532 or Cy3), then mixing and hybridizing them on a chemically treated glass printed with probes, or fragments of genes. The level of hybridization between a strand of labeled DNA and a probe present on the array is measured by scanning the fluorescence of spots in order to quantify the expression based on the quality and number of pixels for each spot.
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