Publications by authors named "Mohamed M H Arief"
Article Synopsis
- Selenium-containing heterocyclic compounds, particularly new pyridine derivatives, have become a focus of interest for their potential as bioactive molecules with antimicrobial properties.
- A one-pot multicomponent approach using solvent-free microwave irradiation was utilized for their synthesis, with spectroscopic techniques confirming the structures of the compounds.
- Antimicrobial activity was tested via the agar diffusion method, revealing some derivatives showing significant antibacterial and antifungal activity, particularly one that demonstrated the strongest performance, supported by molecular docking and DFT calculations for further insights into molecular geometry and reactivity.
Background: The synthesis of a novel series of oxadiazine-4-thione biological molecules was executed through the incorporation of the ortho-, meta-, and para-benzoyl isocyanates to the tetrabromophthalimide nucleus.
Objectives: A one-pot multicomponent methodology in a solvent-free microwave irradiation environment was employed to afford this series of oxadiazine-4-thione, deriving a comparison with the conventional method. Subsequently, the yielded derivatives were subjected to further biological assessment.
Liver X Receptor (LXR) agonists have been reported as a potential treatment for atherosclerosis, Alzheimer's disease and hepatitis C virus (HCV) infection. We have designed and synthesized a series of potent compounds based on a 1,2,4-triazole scaffold as novel LXR modulators. In cell-based cotransfection assays these compounds generally functioned as LXR agonists and we observed compounds with selectivity towards LXRα (7-fold) and LXRβ (7-fold) in terms of potency.
View Article and Find Full Text PDFNuclear hormone receptors represent a large family of ligand-activated transcription factors that include steroid receptors, thyroid/retinoid receptors, and orphan receptors. Among nuclear hormone receptors, the liver X receptors have emerged as very important drug targets. These receptors regulate some of the most important metabolic functions, and they were also identified as anti-inflammatory transcription factors and regulators of the immune system.
View Article and Find Full Text PDFThis study presents a method validation for extraction and quantitative analysis of azoxystrobin residues in green beans and peas using HPLC-UV and the results confirmed by GC-MS. The employed method involved initial extraction with acetonitrile after the addition of salts (magnesium sulfate and sodium chloride), followed by a cleanup step by activated neutral carbon. Validation parameters; linearity, matrix effect, LOQ, specificity, trueness and repeatability precision were attained.
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