Protection by tocotrienols against hypercholesterolaemia and atheroma.

Antioxidants such as tocotrienols may protect against atherosclerosis since tissue injury from free radicals is a final common pathway of damage in arterial disease. In this study, the effects of tocotrienols on serum cholesterol, lipid peroxides, and aorta atheroma were assessed in rabbits fed an atherogenic diet for 12 weeks. Tocotrienols were more effective than tocopherols in preventing increases in serum LDL (p = 0.

The effects of propranolol on skeletal muscle contraction, lipid peroxidation products and antioxidant activity in experimental hyperthyroidism.

1. The mean levels of lipid peroxidation products, namely conjugated diene and malonaldehyde, were increased in the soleus muscles of hyperthyroid cats, while the mean glutathione peroxidase activity was decreased. No corresponding similar changes were noted in the fast extensor digitorum longus muscles and serum.

Prevention of oral mucositis in radiation therapy: a controlled study with benzydamine hydrochloride rinse.

Benzydamine hydrochloride rinse was shown to prevent oral mucositis in radiation therapy. Prevention of mucositis allows reduction in morbidity of one of the therapy limiting complications of radiotherapy for cancer therapy.

Plasma antioxidants and lipid peroxidation products in Duchenne muscular dystrophy.

Lipid peroxidation (LPX) products in plasma were elevated in Duchenne muscular dystrophy (DMD) patients (n = 9) compared with an age- and sex-matched group of controls (n = 10). Trichloroacetic acid-precipitable thiobarbituric acid-reactive substances (TBARS) were increased by 35% (p less than 0.01), conjugated dienes by 77% (p less than 0.

Topical ketoconazole for fungal keratitis.

Six patients (five men and one woman, 19 to 57 years old) with laboratory-proven fungal corneal infections were successfully treated with topical ketoconazole, a synthetic imidazole derivative. No signs of progression of the corneal infection were seen after the antifungal therapy was initiated. The clinical signs of corneal infection disappeared after three (Aspergillus infections) to seven weeks (Fusarium infections) of ketoconazole therapy.

The comparative multiple-dose intraocular pressure responses of nadolol and timolol in glaucoma and ocular hypertension.

In a double-masked clinical study the relationship between acute and chronic IOP responses to topical Nadolol 2% solution and Timolol 0.25% solution twice daily was investigated in 10 patients with glaucoma or ocular hypertension. Both drugs were evaluated in an intra-individual comparison over 4 weeks.