Design, synthesis and mechanistic study of new benzenesulfonamide derivatives as anticancer and antimicrobial agents carbonic anhydrase IX inhibition.

Changes in gene expression cause uncontrolled cell proliferation and consequently tumor hypoxia. The tumor cells shift their metabolism to anaerobic glycolysis with a significant modification in pH. Therefore, an over expression of carbonic anhydrase IX (CA IX) genes was detected in many solid tumors.