Publications by authors named "Mohamed Hussam Aswad"
JAK2V617F mutation and circulating extracellular vesicles in essential thrombocythemia.
Clin Hemorheol Microcirc
October 2023
The clinical course of essential thrombocythemia (ET) is complicated with thrombosis which significantly impacts patients' mortality. Studies have identified JAK2V617F mutation as an independent risk factor for thrombosis. Circulating extracellular vesicles (EVs) were evaluated in several studies regarding myeloproliferative neoplasms and thrombosis as potential biomarkers.
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- Thrombosis is a major complication in patients with BCR-ABL1 negative myeloproliferative neoplasms (MPN) and significantly affects mortality rates.
- Risk factors for increased thrombosis risk include age, previous history of thrombosis, the presence of the JAK2V617F mutation, and cardiovascular health.
- The study finds that patients with the JAK2V617F mutation have a much higher risk of thrombosis, with several independent factors identified that require tailored management strategies.
Background/aim: This work aimed to prospectively evaluate the clinical significance of circulating microparticles (MPs) in relation to thrombotic risk factors and thrombotic complications in patients with BCR/ABL1-negative myeloproliferative neoplasms (MPN).
Patients And Methods: In a cohort of 206 patients with MPN, MPs' procoagulant activity was measured by the Zymuphen functional assay in 429 samples, while platelet- and erythrocyte-MPs were enumerated by flow cytometry in 558 samples.
Results: MPN patients had higher MP levels than the control group.