Publications by authors named "Mohamed Houmed Aboubaker"
Article Synopsis
- Carbapenem resistance poses a significant public health risk in sub-Saharan Africa, particularly at the intersections of human, animal, and environmental factors, as shown in a study conducted in Djibouti City.
- The study analyzed 1650 samples, including urine, hospital specimens, livestock feces, fish, and water, revealing a low overall prevalence of 1.9% CP-GNB, with higher rates in fish (11.7%) and water (10%).
- Genome sequencing identified key bacterial species associated with resistance and indicated the presence of epidemic clones, suggesting horizontal gene transfer plays a role in the spread of carbapenem resistance across different environments.
Article Synopsis
- Antimicrobial resistance (AMR) is rapidly increasing globally, particularly in developing countries, with a notable rise in carbapenem-resistant bacteria, yet data from these regions is scarce.
- A study conducted in Djibouti analyzed 256 isolates, revealing that a significant majority (91.8%) were Gram-negative bacteria, with 8.5% exhibiting carbapenem resistance, predominantly from specific E. coli and other species.
- The research identified various carbapenemase genes in these resistant isolates and emphasized the importance of ongoing molecular screening to monitor and control the spread of resistance within clinical settings.
Background: The Republic of Djibouti is a malaria endemic country that was in pre-elimination phase in 2006-2012. From 2013, however, malaria has re-emerged in the country, and its prevalence has been increasing every year. Given the co-circulation of several infectious agents in the country, the assessment of malaria infection based on microscopy or histidine-rich protein 2 (HRP2)-based rapid diagnostic tests (RDT) has shown its limitations.
View Article and Find Full Text PDFThe emergence and spread of multidrug resistant Enterobacterales (MDR-E) are a global public health issue. This problem also concerns urinary tract infections (UTI), which are the second most frequent infections after respiratory infections. The objective of this study was to determine MDR-E frequency and to characterize MDR-E isolates from patients with community-acquired UTIs in Djibouti, Republic of Djibouti.
View Article and Find Full Text PDFSince the start of COVID-19 pandemic the Republic of Djibouti, in the horn of Africa, has experienced two epidemic waves of the virus between April and August 2020 and between February and May 2021. By May 2021, COVID-19 had affected 1.18% of the Djiboutian population and caused 152 deaths.
View Article and Find Full Text PDFSeveral marine pathogens are thought to be implicated in the summer mortality phenomenon that strikes the Pacific oyster stocks (Crassostrea gigas) in Europe since more than a decade. Although, since 2008, a herpes virus variant (microvar) is considered the main responsible for juvenile mortalities, the role of several associated bacteria is less clear. One of these, Vibrio aestuarianus, has often been detected in moribund oysters, and laboratory challenges proved its involvement in oyster death.
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