Publications by authors named "Mohamed Hemeda"
Azithromycin is a broad-spectrum antibiotic commonly used to treat bacterial infections but is associated with adverse cardiac effects, including oxidative damage and myocardial inflammation. This study aims to explore the histopathological and biochemical changes, including serum interleukin-10 levels, induced by azithromycin in the hearts of male albino rats and to evaluate the protective role of combined selenium and vitamin E treatment. Forty rats were divided into four groups: a control group, an azithromycin treatment group, selenium and vitamin E treatment group, and a combined treatment group receiving both azithromycin, selenium, and vitamin E.
View Article and Find Full Text PDFArticle Synopsis
- A case-control study in Egypt involved 51 patients with acute opioid intoxication compared to 51 controls, focusing on the cardiovascular complications associated with substance abuse.
- Findings revealed serious cardiac issues among opioid-intoxicated patients: 39.2% experienced hypotension, 72.5% had ECG changes, with sinus bradycardia being most prevalent at 51%.
- The study highlighted that elevated cardiac enzymes correlated with longer ICU stays and increased mortality, stressing the importance of early cardiac evaluation to improve patient outcomes.
Investigation of metronidazole resistance-associated mutations and virulence genotypes in helicobacter pylori isolates from the Egyptian population: A cross-sectional study.
J Infect Chemother
October 2024
Article Synopsis
- This study investigates metronidazole resistance and virulence genotypes in H. pylori from Egyptian patients, highlighting the public health issue of antibiotic resistance in this bacterium.
- The research involved collecting gastric biopsies from 250 symptomatic patients and using molecular techniques to analyze antibiotic resistance mutations and virulence factors.
- Findings showed that 43.6% of H. pylori isolates were resistant to metronidazole, with significant links between resistance and virulence genes, suggesting that genetic factors may contribute to how the bacteria resist treatment.
Article Synopsis
- Acute poisoning is a serious health concern for children, especially preschoolers (ages 3-6), due to their natural curiosity and frequent accidents, with 83% of cases being accidental poisonings.
- A study of 106 children at Damietta General Hospital in Egypt found household cleaning products and petroleum products were the most common toxic agents, with clinical outcomes showing a 94.3% cure rate but a 5.7% mortality rate.
- The research underscores the importance of parental education and preventive measures to mitigate risks, particularly in rural areas, and supports the use of the Poison Severity Score (PSS) to inform clinical care in pediatric patients.
Background: Domestic abuse is a widespread health issue that negatively impacts both mental health and quality of life.
Objectives: To determine the prevalence of domestic violence and anxiety among women visiting primary healthcare facilities in the rural Ismailia governorate.
Methods: Between October 2021 and December 2021, a cross-sectional study was conducted.
Indomethacin (INDO) is an NSAID with remarkable efficacy and widespread utilization for alleviating pain. Nevertheless, renal function impairment is an adverse reaction linked to INDO usage. Nifuroxazide (NFX), an oral nitrofuran antibiotic, is frequently employed as an intestinal anti-infective agent.
View Article and Find Full Text PDFCisplatin is a chemotherapeutic agent usually used in treating different patterns of malignancies. One of the significant apparent complications of cisplatin chemotherapy is brain toxicity. The present study was conducted to evaluate the protective effects of lansoprazole on cisplatin-induced cortical intoxication.
View Article and Find Full Text PDFArticle Synopsis
- Prostatic epithelial cells produce vitamin D, which plays a role in prostate growth regulation and has antiproliferative effects against prostate cancer through the vitamin D receptor (VDR).
- A case-control study was conducted with two groups: one with benign prostate hyperplasia and the other with newly diagnosed prostate cancer, examining various health metrics and genetic polymorphisms.
- Results revealed significant differences in genotype frequencies and prostate-specific antigen levels between cancer patients and controls, suggesting that the genetic polymorphism might serve as a diagnostic and prognostic marker for prostate cancer in Egyptian men.
Studying bladder cancer molecular biology revealed the presence of genetic alterations. So, detection of molecular biomarkers that help in monitoring the disease, evaluating the prognosis of the patients, and their response to therapy is needed. In this study, we investigated the expression and the prognostic significance of SATB-1 and ERBB2 mRNA and protein by quantitative RT-PCR and immunohistochemical analysis in urothelial bladder cancer cases and the surrounding normal bladder tissue.
View Article and Find Full Text PDF