Publications by authors named "Mohamed Hadjeri"
We report the synthesis of 5-hydroxy-7-methoxy-2-phenyl-4-quinolones and their biological activity as antitumor agents. These molecules were initially evaluated for their ability to induce cell cycle arrest in the G2/M phase. Compounds that showed significant G2/M cell cycle arrest were tested for antiproliferative activity using both the MTT assay and the NCI in vitro 60 cell line human tumor screen.
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- Flavonoid derivatives were synthesized and tested for their effects on P-glycoprotein (Pgp)-mediated multidrug resistance (MDR) in cancer cells, focusing on subclasses like chromones, azaisoflavones, and aurones.
- Among the compounds tested, three—4a, 5, and 6—showed significant ability to enhance the effects of the chemotherapy drug daunorubicin in resistant K562 cells and increased the uptake of a fluorescent probe used to assess Pgp activity.
- The compound 4a proved to be the most effective in reversing resistance, outperforming the standard reference drug cyclosporin A, while showing minimal impact on other drug transport mechanisms and limited cell death compared