In vitro effects of three antidepressant drugs on plasma paraoxonase activity.

Background: Paraoxonase 1 (PON1) is important in organophosphates and xenobiotic metabolism and as an antioxidant bio-scavenger. PON1 activity was shown to significantly decrease in depressed patients after antidepressant treatment instauration. Our aim was to investigate the in vitro inhibitory effects of three antidepressants (imipramine, amitriptyline and fluoxetine) on PON1 activity.

Interference of tobacco smoke with immunochromatography assay for urinary drug detection.

Background: This study aimed to evaluate the interference of tobacco smoke on immunochromatography assay of urinary drug detection.

Methods: Our study included 256 voluntary subjects (143 passive smokers and 113 current smokers). Cotinine was measured by immunoenzymatic method and thiocyanates (SCN(-)) by selective electrode.