Synthesis, modeling and biological evaluation of hybrids from pyrazolo[1,5c]pyrimidine as antileishmanial agents.

Aim: A new series of pyrazolo[1,5-c]pyrimidines were synthesized by different hybridization strategies.

Methodology: All structures were confirmed by IR, H, C, H-C heteronuclear multiple-quantum correlation (HMQC) spectra and microanalysis. They were evaluated for their in vitro antileishmanial activity against miltefosine and amphotericin B deoxycholate as reference drugs.