Enhanced surface functionalization of 2D molybdenum/tin chalcogenide nanostructures for effective SERS detection of .

Surface Enhanced Raman Spectroscopy (SERS) is a highly sensitive analytical technique used for fingerprint recognition of molecular samples. The SERS effect, which enhances Raman scattering signals, has been the subject of extensive research over the past few decades. More recently, the commercialization of portable Raman spectrometers has brought SERS closer to real-world applications.

The Anti-proliferative Effect, Apoptotic Induction, and Cell Cycle Arrest of Tetra Halo Ruthenate Nanocomposites in Different Human Cancer Cell Lines.

Chemotherapy is the most common cancer treatment, and metallic anticancer compounds have generated increasing amounts of interest since the discovery of cisplatin. More recently, scientists have focused on ruthenium-based compounds as alternatives for platinum compounds, which seem like ideal therapeutic anticancer alternatives to platinum derivatives. The present study aims to assess whether one or more of three Ruthenium-based nanocomposites, namely Ru+Lysine+CTAB (RCTL), Ru+CTAB (RCT), and Ru+Lysine (RL) exhibit pronounced anti-proliferative properties against different cancer cells.

Safety and efficacy of platelet-rich plasma injection for treatment of erectile dysfunction: a prospective randomized controlled study.

Background: Affected sexual relationships affect both the quality of life of men and women. Platelet-derived therapies are becoming increasingly popular in various medical and surgical fields because of their ability to aid in tissue healing and vascular remodeling. This study aimed to assess the safety and effectiveness of platelet-rich plasma (PRP) injections in treating patients with erectile dysfunction (ED).

Enhancing wheat tolerance to salinity using nanomaterials, proline, and biochar-inoculated with .

Salinity negatively impacts crop production by affecting physiological and biochemical processes in plants. This study investigates the effectiveness of Nano-ZnO (NZn), proline (PA), Nano-TiO (NTi), Nano-SiO (NSi)), and biochar inoculated with (OSBS) in enhancing wheat tolerance to salinity stress. Pot experiments were conducted under saline conditions with varying rates of biochar and foliar applications.

The neuroprotective effects of alpha lipoic acid in rotenone-induced Parkinson's disease in mice via activating PI3K/AKT pathway and antagonizing related inflammatory cascades.

Parkinson's disease (PD) is an idiopathic disease caused by the loss or degeneration of the dopaminergic (dopamine-producing) neurons in the brain and characterized by various inflammatory and apoptotic responses in the neuronal cells. Phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) axis is responsible for neuronal survival by providing a number of anti-inflammatory and anti-apoptotic milieu that prevent the progression of PD. Alpha-lipoic acid (ALA) is a natural cofactor that has antioxidant capacity and contributes to various metabolic processes.

Polyphenols: Chemistry, bioavailability, bioactivity, nutritional aspects and human health benefits: A review.

Polyphenols, including phenolics, alkaloids, and terpenes, are secondary metabolites that are commonly found in fruits, vegetables, and beverages, such as tea, coffee, wine, chocolate, and beer. These compounds have gained considerable attention and market demand because of their potential health benefits. However, their application is limited due to their low absorption rates and reduced tissue distribution efficiency.

Decontamination of Chlorpyrifos Residue in Soil by Using (Lamiales: Lamiaceae) for Phytoremediation and Two Bacterial Strains.

This study utilizes (MI) for the first time to investigate the uptake and translocation of chlorpyrifos (CPF; 10 µg g) from soil, introducing a new approach to improve the efficacy of this technique, which includes using biosurfactants ( and ) at 10 CFU/mL to degrade CPF under greenhouse conditions. Moreover, antioxidant enzymes, including superoxide dismutase (SOD) and peroxidase (Prx), and oxidative stress due to hydrogen peroxide (HO) and malondialdehyde (MDA) in MI roots and leaves were evaluated under CPF stress. Our results demonstrated that amending soil with MI and followed by significantly reduced CPF levels in the soil ( > 0.

Activation of alpha-7 nicotinic acetylcholine receptor by tropisetron mitigates 3-nitropropionic acid-induced Huntington's disease in rats: Role of PI3K/Akt and JAK2/NF-κB signaling pathways.

Huntington's disease (HD) is an inheritable autosomal-dominant disorder that targets mainly the striatum. 3-Nitropropionic acid (3-NP) induces obvious deleterious behavioral, neurochemical, and histological effects similar to the symptoms of HD. Our study aimed to examine the neuroprotective activity of tropisetron, an alpha-7 neuronal nicotinic acetylcholine receptor (α-7nAChR) agonist, against neurotoxic events associated with 3-NP-induced HD in rats.

Nicorandil attenuates cisplatin-induced acute kidney injury in rats via activation of PI3K/AKT/mTOR signaling cascade and inhibition of autophagy.

Cisplatin is a highly effective antitumor agent, but its clinical use is limited due to critical adverse reactions including acute kidney injury (AKI). Nicorandil is an approved antianginal agent decreasing ischemia by potassium channel opening. The aim of this study was to investigate the nephroprotective effects of nicorandil and the possible role of activating PI3K/AKT/mTOR pathway in ameliorating cisplatin-induced AKI.

Management of penile post-circumcision ischemia by pentoxifylline infusion and hyperbaric oxygen therapy.

Background: Post-circumcision penile ischemia is a devastating complication. We will present our experience in managing children with various forms of penile ischemia.

Materials And Methods: This cohort prospective observational and interventional study was performed on all male children with post-circumcision penile ischemia between April 2017 and October 2021.

The Impact of Laparoscopic Sleeve Gastrectomy on Thyroid Functions in Egyptian Patients with Obesity.

Background: Sleeve gastrectomy (SG) continues to be one of the most popular bariatric procedures all over the world. Thyroid-stimulating hormone (TSH) frequently shows a slight elevation in patients with obesity. The effect of SG on thyroid hormones has been rarely investigated.

Foreskin restorers: insights into motivations, successes, challenges, and experiences with medical and mental health professionals - An abridged summary of key findings.

Demographically diverse surveys in the United States suggest that 5-10% of non-voluntarily circumcised American males wish that they had not been circumcised. Similar data are unavailable in other countries. An unknown proportion of circumcised males experience acute circumcision-related distress; some attempt to regain a sense of bodily integrity through non-surgical foreskin restoration.

L. Nanoemulsion Mitigates Cisplatin-Induced Chemobrain via Reducing Neurobehavioral Alterations, Oxidative Stress, Neuroinflammation, and Apoptosis in Adult Rats.

Cisplatin (Cis) is a potent chemotherapeutic agent; however, it is linked with oxidative stress, inflammation, and apoptosis, which may harmfully affect the brain. L. (HP L.

Protocatechuic acid ameliorates lipopolysaccharide-induced kidney damage in mice via downregulation of TLR-4-mediated IKBKB/NF-κB and MAPK/Erk signaling pathways.

Acute kidney injury (AKI) is a very critical cause of death in the whole world. Lipopolysaccharide (LPS) induces kidney damage by activating various deleterious inflammatory and oxidative pathways. Protocatechuic acid, a natural phenolic compound, has shown to exert beneficial effects against oxidative and inflammatory responses.

Rosuvastatin and co-enzyme Q improve high-fat and high-fructose diet-induced metabolic syndrome in rats via ameliorating inflammatory and oxidative burden.

The prevalence of metabolic syndrome (MetS) has been rising alarmingly and it has now become a global concern causing an enormous economic burden on the health care system. MetS is generally linked to complications in lipid metabolism, oxidative stress and low grade inflammation. The aim of the current study was to evaluate the effect of rosuvastatin, co-enzyme Q10 (CoQ10), and their combination on blood pressure, blood sugar, dyslipidemia, and liver function in rats with MetS induced by high fructose and high fat diet (HF-HFD) and the possible underlying mechanism.

Three-Dimensional Boundary Element Strategy for Stress Sensitivity of Fractional-Order Thermo-Elastoplastic Ultrasonic Wave Propagation Problems of Anisotropic Fiber-Reinforced Polymer Composite Material.

A new three-dimensional (3D) boundary element method (BEM) strategy was developed to solve fractional-order thermo-elastoplastic ultrasonic wave propagation problems based on the meshless moving least squares (MLS) method. The temperature problem domain was divided into a number of circular sub-domains. Each node was the center of the circular sub-domain surrounding it.

Fractional boundary element solution of three-temperature thermoelectric problems.

The primary goal of this article is to propose a new fractional boundary element technique for solving nonlinear three-temperature (3 T) thermoelectric problems. Analytical solution of the current problem is extremely difficult to obtain. To overcome this difficulty, a new numerical technique must be developed to solve such problem.

Pigmentary complications after non-medical male circumcision.

Background: A wide spectrum of complications are reported after male circumcision (MC), the non-aesthetic complications are well known, but the pigmentary complications scale are not reported precisely.

Methods: This is a prospective cohort study of 550 circumcised boys; aged from 6 months to 14 years (62% aged 5 years) who were examined and appropriately investigated for the incidence of pigmentary complications after circumcision. Most diagnoses were clinically, but dermoscopy was done for 17 case and a skin biopsy for 14 cases.

Pyrimidine-5-carbonitrile based potential anticancer agents as apoptosis inducers through PI3K/AKT axis inhibition in leukaemia K562.

A novel series of 4-(4-Methoxyphenyl)-2-(methylthio)pyrimidine-5-carbonitrile was developed linked to an aromatic moiety -containing bridge and then evaluated for their cytotoxic activity against MCF-7 and K562 cell lines. Seven compounds exhibited the highest activity against both cell lines where compounds and were the most active against K562 cell line. Exploring their molecular mechanisms by enzyme inhibition assay on PI3Kδ/γ and AKT-1 showed that compound was promising more than with IC = 6.

Boundary Element and Sensitivity Analysis of Anisotropic Thermoelastic Metal and Alloy Discs with Holes.

The main aim of this paper was to develop an advanced processing method for analyzing of anisotropic thermoelastic metal and alloy discs with holes. In the boundary element method (BEM), the heat impact is expressed as an additional volume integral in the corresponding boundary integral equation. Any attempt to integrate it directly will necessitate domain discretization, which will eliminate the BEM's most distinguishing feature of boundary discretization.

Efficient Use of Graphene Oxide and Silica Fume in Cement-Based Composites.

Incorporation of graphene oxide (GO) and silica fume (SF) to cement composites enhances their mechanical properties if suitable proportional amounts of GO and SF are used. This study presents a simplified approach to determine experimentally the optimum GO and SF contents that should be added to the cementitious mixture to obtain a proper and stable dispersion of GO sheets within the cement matrix. Composite mortar specimens with different GO and SF contents were designed and tested under flexural and compression loading.

Placenta accreta risk-antepartum score in predicting clinical outcomes of placenta accreta spectrum: A multicenter validation study.

Objective: To validate the use of placenta accreta risk-antepartum (PAR-A) score as a predictive tool of clinical outcomes of placenta accreta spectrum (PAS).

Methods: This is a prospective study, conducted in six PAS specialized centers in six different countries. The study was conducted between October 1, 2020 and March 31, 2021.

Prediction of clinical outcomes in women with placenta accreta spectrum using machine learning models: an international multicenter study.

Introduction: Placenta accreta spectrum is a major obstetric disorder that is associated with significant morbidity and mortality. The objective of this study is to establish a prediction model of clinical outcomes in these women.

Materials And Methods: PAS-ID is an international multicenter study that comprises 11 centers from 9 countries.