Publications by authors named "Mohamed Elhefny"

Acute kidney injury (AKI) is a life-threatening complication that accompanies rhabdomyolysis. Daidzein is a dietary isoflavone that has various biological activities. This study examined the therapeutic potential of daidzein and the underlying mechanisms against AKI induced by glycerol in male rats.

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Irritable bowel syndrome (IBS) is a commonly found global functional pathology with no detectable structural changes. It affects the quality of life and often coexists with psychiatric and somatic issues. We reviewed all articles published between 1990 and April 2023.

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Background Headaches are a prevalent form of pain experienced in the skull, face, and facial structures, categorized into two types: primary and secondary. Primary headaches are more frequently observed in children and can be triggered by sleep disturbances, vision problems, malnutrition, and other medical conditions. Despite their prevalence among children, these headaches often go unrecognized and untreated, and there seems to be insufficient parental awareness regarding childhood headaches.

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Background Osteoarthritis (OA) is a chronic progressive disease that leads to the destruction of the articular cartilage inside the joint. OA is a common everyday musculoskeletal disorder worldwide, and it is believed that OA is triggered by genetics and environmental factors, including age, which is the most significant risk factor. This study aimed to investigate the general population's knowledge of OA and its related risk factors in Makkah, Saudi Arabia.

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Myocardial infarction (MI) is an instant ischemic death of cardiomyocytes that remains a major global cause of mortalities. MI is accompanied by oxidative, inflammatory, apoptotic, and fibrotic insults. Protocatechuic acid (PCA) is a polyphenolic compound with various potent biological activities.

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5-Fluorouracil (5-FU) is a chemotherapy used to treat many types of cancer. Cardiotoxicity is one of the common drawbacks of 5-FU therapy. Quercetin (Qu) is a bioflavonoid with striking biological activities.

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Article Synopsis
  • * Thymoquinone (TQ) shows protective effects against AgNPs-induced liver and kidney toxicity in rats by normalizing serum markers and enhancing antioxidant enzyme activity.
  • * TQ also reduces inflammation and apoptosis in liver and kidney tissues, suggesting it can mitigate the harmful effects of AgNPs and improve their safety for use.
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Arsenic is a toxic metalloid abundantly found in nature and used in many industries. Consumption of contaminated water mainly results in human exposure to arsenic. Toxicity (arsenicosis) resulting from arsenic exposure causes cerebral neurodegeneration.

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Egypt is one of the highest prevalence rates of hepatitis C virus (HCV) infection worldwide. HCV is among major reasons for chronic liver diseases. MicroRNA (miRNAs), small noncoding regulatory molecules play a key role in the pathogenesis of liver.

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