Publications by authors named "Mohamed Elbasiony"
Background: Psoriasis is a common chronic systemic disease affecting the skin, nails, and joints. Nails are commonly associated with a greater severity of the disease. Radiofrequency (RF) is a nonionizing radiation that provides energy originating from electric current to generate heat inside the dermis with anti-inflammatory effects.
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- The study evaluates the effectiveness of macroscopic on-site evaluation (MOSE) during endoscopic ultrasound-guided fine-needle aspiration/biopsy (EUS-FNA/FNB) in diagnosing solid lesions, particularly focusing on histological core sample adequacy.
- Conducted across 16 medical centers in Egypt, Iraq, and Morocco, the study involved over 1000 patients and revealed that a significant majority of biopsied samples were adequate for histological evaluation, demonstrating a high diagnostic yield.
- Results indicated that FNB needles performed best in terms of sensitivity and sample quality, highlighting the potential of MOSE as a valuable alternative to traditional rapid on-site evaluation methods.
Article Synopsis
- MAFLD (Metabolic Dysfunction-Associated Fatty Liver Disease) is becoming more common, and it can lead to serious liver problems called MAFLD-ACLF, but what affects patient recovery isn't fully known yet.
- In a study, researchers looked at data from patients with MAFLD-ACLF to understand their health conditions and see who survived after 90 days, finding that about 51% of patients did survive.
- They discovered new scoring systems to better predict survival, which included factors like diabetes and the causes of liver damage, and these new scores worked better than older ones.
Article Synopsis
- - Nail psoriasis is a tough-to-treat, chronic inflammatory condition that can severely impact quality of life and is linked to greater psoriasis severity, as well as anxiety.
- - A study examined the effectiveness of the long-pulsed 1064 nm Nd: YAG laser in treating fingernail psoriasis compared to untreated control nails by assessing various factors including the NAPSI score and ultrasonographic measures.
- - Results showed significant improvement in the laser-treated group for several clinical and ultrasonographic metrics, while the control group showed only a slight, non-significant improvement, indicating that the Nd: YAG laser may be beneficial for managing nail psoriasis.
Background: Early detection of esophageal varices (EV) before the first attack of bleeding is crucial for primary prophylaxis. The current work aims to investigate the use of a combination of FibroScan and platelet count as noninvasive means to identify EV in patients with compensated cirrhosis.
Methods: Sixty-two patients with compensated hepatitis C virus (HCV)-related cirrhosis were divided into two groups with and without EV.
Vibration Controlled Transient Elastography in Screening for Silent Liver Diseases.
Eur J Gastroenterol Hepatol
October 2023
Objectives: The objective of this study was to screen for significant hepatic fibrosis or steatosis in asymptomatic, apparently healthy subjects by using Vibration-controlled transient elastography and controlled attenuation parameter (CAP).
Methods: Prospectively, 433 asymptomatic apparently healthy adults were included. Fibroscan/CAP examination was performed for all of them.
Background And Aim: Indeterminate biliary stricture (IBS) is a frequently encountered clinical problem. In this study, we aimed to highlight the clinical characteristics, risk factors and diagnostic outcomes of patients presented with indeterminate biliary stricture.
Method: A Retrospective multicenter study included all patients diagnosed with IBS in the participating centers between 2017 and 2021.
Background: Hepatitis C virus (HCV) is a known risk factor for hepatocellular carcinoma. Several epidemiological studies have pointed out to an association of HCV infection with other extrahepatic malignancies. The role of chronic HCV in breast cancer causation is less clear.
View Article and Find Full Text PDFThe new anti-hepatitis C virus (HCV) molecules improve treatment regimens and outcomes, but there are drawbacks. New combinations should target the HCV infectious cycle and be effective against all HCV genotypes. We developed the novel formulation Catvira, composed of epigallocatechingallate (EGCG) + sofosbuvir + ribavirin.
View Article and Find Full Text PDFBackground & Aims: Hepatocellular carcinoma (HCC) risk persists after hepatitis C virus (HCV) eradication with direct-acting antivirals (DAAs), particularly in patients with cirrhosis. Identifying those who are likely to develop HCC is a critical unmet medical need. Our aim is to develop a score that offers individualized patient HCC risk prediction.
View Article and Find Full Text PDFEmergence of new molecules acting directly on the hepatitic C virus (HCV) has improved treatment outcomes. However, there is a risk of selecting viral escape mutants, so a new combination is needed using different inhibitors that target different steps of the HCV infectious cycle. Novel single tablet formulations were developed: Dactavira, composed of sofosbuvir (SOF) 400 mg/daclatisvir (DCV) 60 mg/epigallocatechin gallate (EGCG) 400 mg without ribavirin (RBV); and Dactavira plus, which includes RBV 800 mg.
View Article and Find Full Text PDFBackground: Egypt has one of the highest prevalences and burdens of hepatitis C virus (HCV) worldwide, and a large government treatment programme. However, identifying and treating people who are infected in rural communities can be a substantial challenge. We designed and evaluated a comprehensive community-led outreach programme for prevention, testing, and treatment of HCV infection in one village in northern Egypt, with the goal to eliminate HCV infection from all adult villagers, and as a model for potential adoption in rural settings.
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- The study assessed the effectiveness and safety of ledipasvir/sofosbuvir alone and with ribavirin for treating hepatitis C virus genotype 4 in Egyptian patients, both with and without cirrhosis.
- The research included a total of 255 patients who were assigned to different treatment durations (8 or 12 weeks) and combinations based on their treatment history and cirrhosis.
- Results showed high sustained virological response rates (SVR12) across all groups, particularly highlighting that non-cirrhotic treatment-naive patients had an SVR12 rate of 95% with 8 weeks of treatment, while all previously treated patients achieved SVR12 when given the combination therapy.