Publications by authors named "Mohamed Elbahoty"
RANKL and its receptor RANK play a vital role in osteoclastogenesis. RANK primarily recruits TRAFs to promote osteoclastogenesis but also contains an TRAF-independent motif (IVVY), which mediates osteoclast lineage commitment in vitro. Here, we have developed knockin mice in which inactivating mutations are introduced in the IVVY motif (IVVY to IVAF).
View Article and Find Full Text PDFMultiple myeloma (MM) is a clinical disorder characterized by aberrant plasma cell growth in the bone marrow microenvironment. Globally, the prevalence of MM has been steadily increasing at an alarming rate. In the United States, more than 30,000 cases will be diagnosed in 2024 and it accounts for about 2% of cancer diagnoses and more than 2% of cancer deaths, more than double the worldwide figure.
View Article and Find Full Text PDFArticle Synopsis
- - Hypereosinophilic syndrome (HES) is characterized by high eosinophil levels in the blood, organ damage from eosinophils, and the exclusion of other causes for these symptoms.
- - This report discusses two end-stage renal disease patients on hemodialysis who developed HES, presenting symptoms such as itching and low blood pressure during dialysis sessions.
- - Both patients improved with steroid treatment, highlighting the need for awareness of HES in dialysis patients and the ongoing uncertainty regarding the best treatment approach.