Evaluation of Quinazolin-2,4-Dione Derivatives as Promising Antibacterial Agents: Synthesis, In Vitro, In Silico ADMET and Molecular Docking Approaches.

A series of new quinazolin-2,4-dione derivatives incorporating amide/eight-membered nitrogen-heterocycles -, in addition, acylthiourea/amide/dithiolan-4-one and/or phenylthiazolidin-4-one - and -. The starting compound was prepared by reaction of 4-(2,4-dioxo-1,4-dihydro-2-quinazolin-3-yl)-benzoyl chloride with ammonium thiocyanate and cyanoacetic acid hydrazide. The reaction of with strong electrophiles, namely, -aminophenol, -amino thiophenol, and/or -phenylene diamine, resulted in corresponding quinazolin-2,4-dione derivatives incorporating eight-membered nitrogen-heterocycles -.

Synthesis of Palladium Nanoparticles by Electrode-Respiring Biofilms.

Electroactive microorganisms such as can couple organic electron donor oxidation to the respiration of electrode surfaces, colonizing them in the process. These microbes can also reduce soluble metal ions, such as soluble Pd, resulting in metallic nanoparticle (NP) synthesis. Such NPs are valuable catalysts for industrially relevant chemical production; however, their chemical and solid-state syntheses are often energy-intensive and result in hazardous byproducts.

Synthesis, crystal structure, Hirshfeld surface analysis, and DFT calculation of 4-(5-(((1-(3,4,5-trimethoxyphenyl)-1-1,2,3-triazol-4-yl)methyl)thio)-4-phenyl-4-1,2,4-triazol-3-yl)pyridine.

Triazole is considered as a privileged scaffold in medicinal chemistry by virtue of it is diverse biological activity. several drugs currently in the market possess triazole moiety. In this study click chemistry was performed on the pyridine based 1,2,4-triazole-tethered propargyl moiety to afford 4-(5-(((1-(3,4,5-trimethoxyphenyl)-1-1,2,3-triazol-4-yl)methyl)thio)-4-phenyl-4-1,2,4-triazol-3-yl)pyridine The new compound was fully characterized by H NMR, C NMR, HRMS and X-ray diffraction (XRD).

Acremochlorin S and other prenylated chlorophenol antimicrobial metabolites from the fungus Acremonium sp. Strain MNA-F-1.

Chemical prospection for the mycelial extract of the fungus Acremonium sp. Strain MNA-F-1, derived from the inner tissue of anise roots (Pimpnella anisum L., family Apiaceae), led to the isolation and characterization of one previously undescribed natural product, acremochlorin S (1), together with five related derivatives (2-6) and an alkaloidal metabolite, ilicicolin H (7).

An Extremely Rare Presentation of Mucinous Adenocarcinoma Originating From Meckel Diverticulum Masquerading in a Young Woman With Crohn's Disease.

Mucinous adenocarcinoma with signet cell features originating from Meckel diverticulum (MD) is an extremely rare primary malignant tumor. A woman in her 30s presented with multiple episodes of vomiting, abdominal pain, and constipation. She had a history of stricturing Crohn's disease and managed well with steroids, azathioprine, and infliximab.

The journey to LDL-C goal in the era of combination lipid lowering therapy and why it matters for ASCVD patients: a UK perspective.

Objective: We aim to explore the concept of distance and journey to goal, and consideration of these 2 elements a priori when choosing LLT.

Methods: Modelling of expected % LDL-C reductions was carried out on a range of hypothetical patients' baseline LDL-C values prior to any LLT being commenced. Therapies were then added in a stepwise manner based on the pathway demonstrated in current national guidance and compared with goal achievement on a novel LLT optimization pathway implemented in Morecambe Bay NHS Trust.

Long-distance electron transport in multicellular freshwater cable bacteria.

Filamentous multicellular cable bacteria perform centimeter-scale electron transport in a process that couples oxidation of an electron donor (sulfide) in deeper sediment to the reduction of an electron acceptor (oxygen or nitrate) near the surface. While this electric metabolism is prevalent in both marine and freshwater sediments, detailed electronic measurements of the conductivity previously focused on the marine cable bacteria ( Electrothrix), rather than freshwater cable bacteria, which form a separate genus ( Electronema) and contribute essential geochemical roles in freshwater sediments. Here, we characterize the electron transport characteristics of .

CLINICAL FEATURES AND SURGICAL OUTCOMES OF SCLERAL BUCKLE SURGERY FOR PRIMARY RHEGMATOGENOUS RETINAL DETACHMENT: Moorfields Buckle Study.

Purpose: Long-term study to evaluate the clinical and surgical outcomes of scleral buckle (SB) surgery for primary rhegmatogenous retinal detachment (RRD) at a large tertiary eye center.

Methods: Noncomparative, retrospective case series of 589 eyes of 569 patients with primary RRD who underwent SB surgery between 2004 and 2022 with a median follow-up of 6 months. The main outcome measures were best-corrected visual acuity, surgical outcomes, complications, and classification of RRD.

Cytotoxic naphtho- and benzofurans from an endophytic fungus Epicoccum nigrum Ann-B-2 associated with Annona squamosa fruits.

Chemical exploration of the total extract derived from Epicoccum nigrum Ann-B-2, an endophyte associated with Annona squamosa fruits, afforded two new metabolites, epicoccofuran A (1) and flavimycin C (2), along with four known compounds namely, epicocconigrone A (3), epicoccolide B (4), epicoccone (5) and 4,5,6-trihydroxy-7-methyl-1,3-dihydroisobenzofuran (6). Structures of the isolated compounds were elucidated using extensive 1D and 2D NMR along with HR-ESI-MS. Flavimycin C (2) was isolated as an epimeric mixture of its two diastereomers 2a and 2b.

The record of Vannella species (Vannellidae, Discosea, Amoebozoa) from freshwater sources in Dakahlyia Governorate, Egypt.

The River Nile is the main source of fresh water in Egypt, where its water is used for irrigation, drinking, fisheries, industrial uses, and recreation. For sustainable utilization of the River Nile and its branches in the Nile Delta region, it is necessary to monitor regular investigation for the biodiversity of protozoan fauna in the Damietta branch and other freshwater canals in Dakahlyia Governorate. Water samples were collected monthly from different water sources, for 1 year, and examined for protozoans, using phase-contrast microscopy and recorded video films, The genus Vannella Bovee 1965 is recorded for the first time in four freshwater localities: Demietta branch of the River Nile, Mansouria Canal, Bouhia Canal, and Bahr El-Saghir Canal.

Unveiling the Antimicrobial and Larvicidal Potential of Butyrolactones and Orsellinic Acid Derivatives from the Morus alba-derived Fungus Aspergillus terreus via Integrated In vitro and In silico Approaches.

The emergence of multi-drug-resistant microbial strains spurred the search for antimicrobial agents; as a result, two distinct approaches were combined: four in vitro studies and four corresponding molecular docking investigations. Antituberculosis, anti-methicillin-resistant Staphylococcus aureus (anti-MRSA), antifungal, and larvicidal activities of the crude extract, two fractions, and seven isolated compounds from Aspergillus terreus derived from Morus alba roots were explored. The isolated compounds (5 butyrolactones and 2 orsellinic acid derivatives) showed potent to moderate antitubercular activity with MIC values ranging from 1.

Part-II: an update of Schiff bases synthesis and applications in medicinal chemistry-a patent review (2016-2023).

Introduction: Schiff bases are compounds with characteristic features of azomethine linkage (-C=N-). Schiff bases are capable of coordinating with metal ions via azomethine nitrogen. Schiff base derivatives and their metal complexes are known for intriguing novel therapeutic properties.

Assessment of Preoperative Risk Factors for Post-LASIK Ectasia Development.

Purpose: To evaluate preoperative risk factors (mainly those related to corneal topography/tomography) for post-LASIK ectasia development.

Methods: A retrospective case review for post-LASIK ectasia for myopia or myopic astigmatism. The evaluated data included preoperative subjective refraction, method of flap creation, and topometric/tomographic parameters from Oculus Pentacam, including subjective curvature pattern, topometric, elevation, and pachymetric indices from the Belin Ambrosio display "BAD", and the Pentacam Random Forest Index (PRFI).

Community structure, seasonal dynamics, and impact of some biological parameters of the African catfish on the infection level of the helminth parasites.

Fish parasitic diseases impose a major economic concern on aquaculture. Identified parasites of include one monogenean, (gills), three digeneans and sp. (intestine), two cestodes and (intestine) and two nematodes and (intestine and stomach).

Single-tuned passive filter (STPF) for mitigating harmonics in a 3-phase power system.

Numerous integrals of the fundamental frequency are known as harmonics and can be found in power systems or electrical circuitry systems. Non-linear loads occasionally drain current or contains a varying impedance with each period of the AC voltage are often responsible for power system harmonics. This can result in system overheating, system losses, and equipment or system damage.

New Meroterpenoid Derivatives from the Pomegranate-Derived Endophytic Fungus .

In this study, we report the isolation of two new meroterpenoids, miniolutelide D () and miniolutelide E (13--miniolutelide C) (), along with two meroterpenoidal analogues ( and ) and two phenolic compounds ( and ) from the endophytic fungus derived from fruits. Their structures were elucidated using extensive MS, 1D, and 2D NMR spectroscopic analyses as well as by comparing with data in the literature. The absolute configurations of and were determined using TDDFT-ECD calculations.

Memory T Cells Discrepancies in COVID-19 Patients.

The immune response implicated in Coronavirus disease 2019 (COVID-19) pathogenesis remains to be fully understood. The present study aimed to clarify the alterations in CD4 and CD8 memory T cells' compartments in SARS-CoV-2-infected patients, with an emphasis on various comorbidities affecting COVID-19 patients. Peripheral blood samples were collected from 35 COVID-19 patients, 16 recovered individuals, and 25 healthy controls, and analyzed using flow cytometry.

Soluble Iron Enhances Extracellular Electron Uptake by MR-1.

Extracellular electron transfer (EET) is a process that microorganisms use to reduce or oxidize external insoluble electron acceptors or donors. Much of our mechanistic understanding of this process is derived from studies of transmembrane cytochrome complexes and extracellular redox shuttles that mediate outward EET to anodes and external electron acceptors. In contrast, there are knowledge gaps concerning the reverse process of inward EET from external electron donors to cells.