Publications by authors named "Mohamed El-Lakany"
Article Synopsis
- Gene therapy using a targeted adenovirus vector (Ad-SSTR-RGD-TK/GCV) shows promise for treating uterine leiomyoma by selectively inducing cell death in tumor cells while leaving normal cells unharmed.
- An in-vivo study in mice demonstrated that the targeted vector significantly shrank tumor size, reduced cancer cell proliferation markers, and induced apoptosis compared to untargeted vectors, with no spread of the virus to other tissues.
- The findings suggest that this targeted gene therapy approach could be a safe and effective method for treating leiomyoma, warranting further research in preclinical models before human trials.
We present two cases that developed clinical, biochemical and radiological evidences of primary and secondary hyperparathyroidism. In the first case the adenoma was removed through a transcervical incision and in the second case the supernumerary adenoma was removed through sternotomy. Post operatively, patients had normal serum calcium and iPTH with complete disappearance of symptoms.
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