Assessment of Conventional Solvent Extraction vs. Supercritical Fluid Extraction of Khella ( L.) Furanochromones and Their Cytotoxicity.

Background: Khella ( Lam.) fruits (Apiaceae) are rich in furanochromones, mainly khellin and visnagin, and are thus incorporated in several pharmaceutical products used mainly for treatment of renal stones.

Methods: The objective of this study was to compare the yield of khellin and visnagin obtained using different conventional solvents and supercritical fluid extraction (SCFE) with carbon dioxide (containing 5% methanol as co-solvent).