The protective effect of Argan oil and its main constituents against xenobiotics-induced toxicities.

Background: Argan oil (AO) is a vegetable oil extracted from the fruits of Argania spinosa L. tree, belonging to the Sapotaceae family, primarily found in Morocco. Research studies have demonstrated that AO exhibits diverse pharmacological properties, including antioxidant, antimicrobial, anticancer, antiinflammatory, antidiabetic, antihypercholesterolemic, antiatherogenic, and immunomodulatory effects.

Phytomedical compounds as promising therapeutic agents for COVID-19 targeting angiotensin-converting enzyme 2: a review.

Aims: The aim of the present review was to highlight natural product investigations in silico and in vitro to find plants and chemicals that inhibit or stimulate angiotensin-converting enzyme 2 (ACE-2).

Background: The global reduction of incidents and fatalities attributable to infections with SARS-CoV-2 is one of the most public health problems. In the absence of specific therapy for coronavirus disease 2019 (COVID-19), phytocompounds generated from plant extracts may be a promising strategy worth further investigation, motivating researchers to evaluate the safety and anti-SARS-CoV-2 effectiveness of these ingredients.

Pharmacological and phytochemical properties of the genus Buxus: A review.

Background: Buxus plants have been used in traditional medicine for a very long time. The Buxus genus has been used to cure a variety of illnesses.

Objective: This review aimed to provide a literature review on the genus Buxus including its biological and phytochemical properties.

Antihyperlipidemic effect and GC-MS analysis of phytoconstituents from essential oil in rat.

This study aimed to evaluate the effect of () essential oil (EOs) (80 mg/kg) on Triton WR-1339-induced dyslipidemia in Wistar rats. The effect of essential oil (80 mg/kg) on lipid and lipoprotein profile was examined on Triton WR-1339-induced dyslipidemia in rats. Furthermore, the phytochemical evaluation was performed by GC-MS.

Biochemical and toxicity evaluation of Retama sphaerocarpa extracts and in-silico investigation of phenolic compounds as potential inhibitors against HPV16 E6 oncoprotein.

Cervical cancer is a type of cancer which affects the cervix cells. The conventional treatments for cervical cancer including surgery, chemotherapy, and radiotherapy are only effective in premature stages and less effective in late stages of this tumor. Therefore, the therapeutic strategies based on biologically active substances from plants are needed to develop for the treatment of cervical cancer.

Antihypertensive and ACE-2 Inhibitory Effects of in Rats.

Aims: The antihypertensive activity of was tested.

Background: (Thymelaeaceae) is used against hypertension.

Objective: The antihypertensive effect of was evaluated in this study.

The Genus Anabasis: A Review on Pharmacological and Phytochemical Properties.

The genus Anabasis has long been used in phytomedicine. The studied parts of Anabasis species are used as antirheumatic, diuretic, antidotes against poison, anti-erosion, anti-ulcer, and antidiabetic agents, as well as against headache and skin diseases. The objective of the present review was to summarize the phytochemical and pharmacological aspects related to the genus Anabasis.

Comprehensive Review on the Genus : Pharmacological and Phytochemical Properties.

Aims: This review aimed to review the biological, pharmacological, and phytochemical aspects of the genus .

Background: Plants of the genus have been used for a long time in traditional medicine, and they are distributed in the western Mediterranean region to the Middle East, Iran, Mongolia, Burma, and southwest China. The studied parts of species include aerial parts, leaves, branches, seeds, roots, rhizosphere, soil, and whole plants, used to treat several diseases, including sexual disorders, hepatobiliary disorders, eye disorders, skin diseases and hemorrhoids, diarrhea, and effective in the treatment of various ailments such as snake bite, stomach ache, diabetes, wounds, earache and sciatica pain, windbreak dune fixation, feeding of livestock and firewood.

Moroccan Antihypertensive Plants and their Mechanisms of Action.

Background: The use of herbal remedies, medicinal plants, and their derivatives for the treatment and control of hypertension is well-known and widespread throughout Morocco.

Aims: The aim of the study was to review the antihypertensive and vasorelaxant medicinal plants of the Moroccan pharmacopeia.

Objective: To date, no review on Moroccan medicinal plants exhibiting antihypertensive effects has been performed, and their mechanism of action has not been specified.

Evaluation of ACE2 Inhibition by L. and Toxicity Study.

Background: SARS-CoV-2 is a virus that uses ACE2 to enter the host cell.

Aims And Objectives: This study aimed to evaluate the in silico inhibitory activity of polyphenols from Prunus armeniaca (P. armeniaca) on angiotensin-converting enzyme 2 (ACE2).

Potential Antihypertensive Activity of the Aqueous Extract of and its Effect on ACE-2 in Rats.

Aims: This work aimed to investigate the antihypertensive activity of Ammi visnaga.

Background: The aqueous extract of Ammi visnaga has traditionally been used to treat hypertension in Morocco.

Objective: The objective of this investigation was to evaluate the effect of Ammi visnaga aqueous extract (AVAE) on arterial blood pressure, systolic blood pressure (SBP), mean blood pressure (MBP), diastolic blood pressure (DBP), and heart rate (HR) in normotensive and hypertensive rats.

Study of the Antihypertensive Effect of ssp. deliciosa in Albino Wistar Rats.

Aims: The study aimed to investigate the antihypertensive activity of ssp. deliciosa.

Background: ssp , locally known as "", is used in traditional medicine in Morocco as a diuretic and mainly against snake bites.

Alkaloids as Promising Agents for the Management of Insulin Resistance: A Review.

Background: Insulin resistance is one of the main factors that lead to the development of type 2 diabetes mellitus (T2DM). The effect of alkaloids on insulin resistance has been extensively examined according to multiple scientific researches.

Objective: In this work, we aimed to summarize the interesting results from preclinical and clinical studies that assessed the effects of natural alkaloids (berberine, nigelladine A, piperine, trigonelline, capsaicin, nuciferine, evodiamine, mahanine, and magnoflorine) on impaired insulin sensitivity and worsened insulin resistance, which play a pivotal role in the pathogenesis of type 2 diabetes.

Ethnopharmacology, Nutritional Value, Therapeutic Effects, Phytochemistry, and Toxicology of L.: A Review.

Aims: The purpose of this review was to emphasize the nutritional value, and pharmacological and phytochemical properties of , as well as its toxicological evaluation.

Background: Salvia hispanica L. (), also called chia seeds, is an annual herbaceous plant belonging to the family Lamiaceae.

: A Plant with Several Medicinal Properties.

The species L. ( L.) belongs to the family Lamiaceae, native to Europe, North Africa, and the Middle East, and the genus .

Antidiabetic Effect of Star Anise () in Streptozotocin-induced Diabetic Rats.

Aim: The current study aimed to evaluate the antidiabetic potential of Illicium verum fruits.

Background: Illicium verum fruits are frequently used by the Moroccan population in the treatment of diabetes.

Methods: The antihyperglycemic effect of the aqueous extract of Illicium verum fruits (AEIVF) in rats was assessed.

Alkaloids as Vasodilator Agents: A Review.

The pathophysiology of hypertension is often associated with endothelial dysfunction and the impairment of endothelium-dependent vasodilation mechanisms, as well as alterations in vascular smooth muscle (VSM) tone. Natural products, particularly alkaloids, have received increased attention in the search for new vasodilator agents. This review aims to summarize the noteworthy results from and studies that explored the vasodilatory effects of some selected alkaloids (Berberine, Sinomenine, (S)-Reticuline, Neferine, Nuciferine, Villocarine A, 8-Oxo-9-Dihydromakonakine, Harmaline, Harman, and Capsaicin) and the underlying mechanisms implicated.

Antidiabetic and Antidyslipidemic Effects of , an Endemic Plant from Morocco.

Aims: The study aimed to assess the antihyperglycemic and antidyslipidemic activities of .

Background: is an endemic plant of Morocco used in traditional medicine as an alternative treatment for diabetes.

Objective: The study was designed to examine the antihyperglycemic and antidyslipidemicability of aqueous extract of (AMAE) in experimental animal models.

Study of the Analgesic Potential of the Ethanolic Extract of Moroccan L.

Aims: The study aimed to analyze the analgesic activity of L.

Background: L. is a fragrant shrub of the Cistaceae family widespread in the Mediterranean basin, it has various biological activities, including antidiabetic and antihypertensive effects.

A Comprehensive Overview of L.: Its Ethnobotanical Uses, Phytochemistry, Therapeutic Uses, Pharmacological Activities, and Toxicology.

has been largely used in traditional medicine. This study aims to review the pharmacological and phytochemical properties of L and also summarize the pharmacological, photochemical, and toxicological characteristics of . The current review focuses on the distribution, chemical content, and main uses of .

L-Tartaric Acid Inhibits Diminazene-induced Vasorelaxation in Isolated Rat Aorta.

Aims: The study investigated the effect of L-tartaric acid on diminazene-indiuced vasorelaxation.

Background: Diminazene is known to induce vasorelaxation through the stimulation of angiotensin- converting enzyme (ACE-2).

Objective: This work was designed to study the effect of L-tartaric acid on diminazene-induced vasorelaxation using an approach.

Antihyperglycemic Effect of L. Aqueous Extract in Streptozotocin-induced Diabetic Rats.

Background: Traditionally, the aerial parts of Rhamnus alaternus L. have been widely used in Mediterranean countries, including Morocco, to cure diabetes.

Aim: This study aimed to evaluate the antidiabetic effect of Rhamnus alaternus aqueous extract in streptozotocin(STZ)-induced diabetic rats.

Antihypertensive Effect of in Rats.

Aims: The study aimed to investigate the effect of on blood pressure.

Background: is a medicinal plant with several medicinal properties.

Objective: This study aimed to study the vasorelaxant and antihypertensive capacity of the aqueous extract of (E.

L-Tartaric Acid Exhibits Antihypertensive and Vasorelaxant Effects: The Possible Role of eNOS/NO/cGMP Pathways.

Aims: The aim of the study was to investigate the antihypertensive effect of L-Tartaric acid.

Background: L-Tartaric acid (L-TA) is a well-known weak organic acid that naturally occurs in a wide range of fruits, most notably in grapes, tamarind, and citrus.

Objective: The present study aimed to assess the effect of acute and subchronic administration of L-TA on blood pressure parameters in normotensive and hypertensive rats as well as its vasorelaxant potency.

Exhibits Antihypertensive Activity in Hypertensive Rats.

Aims: The present work aimed to assess the antihypertensive activity of Salvia aucheri.

Background: Salvia aucheri (S. aucheri) is an aromatic and medicinal herb belonging to the Lamiaceae family.