Publications by authors named "Mohamed Dermani"
Introduction: The complement system is involved in numerous diseases, through diverse mechanisms and degree of activation. With the emergence of complement targeting therapeutic, simple and accessible tools to evaluate the extent of complement activation are strongly needed.
Methods: We evaluated two multiplex panels, measuring complement activation fragments (C4a, C3a, C5a, Bb, Ba, sC5b9) and intact components or regulators (C1q, C2, C3, C4, C5, FD, FP, FH, FI).
Article Synopsis
- The study aimed to evaluate the Immunoscore (IS) as a potential biomarker for patients with rectal cancer managed by a watch-and-wait (W&W) strategy, focusing on predicting recurrence after treatment.
- It involved 249 patients and analyzed the presence of specific immune cells in pre-treatment biopsies, finding that higher IS scores were associated with better 5-year recurrence-free rates.
- The results indicate that IS is a strong independent predictor of time to recurrence and improves the accuracy of clinical models in assessing patient outcomes.