Innovative synthesis and molecular modeling of actinomycetes-derived silver nanoparticles for biomedical applications.

The rising demand for innovative antimicrobial solutions has shifted focus towards silver nanoparticles (AgNPs), especially those produced through eco-friendly methods. This study introduces a novel approach utilizing actinomycetes strains-Streptomyces albus, Micromonospora maris, and Arthrobacter crystallopoietes-to biosynthesize AgNPs with remarkable antibacterial properties. Through molecular characterization, we identified unique features of these nanoparticles, and computational modeling suggested significant ion-ligand interactions with proteins 6REV and 3K07.

The Ratio of Cysteine-Rich Angiogenic Inducer 61 to MicroRNA -155 Expression as a Preeclampsia Diagnostic Marker and Predictor of Its Severity.

Background: Preeclampsia (PE) is a multisystem pregnancy disorder that increases maternal-perinatal morbidity and mortality significantly. MicroRNA-155 (miR-155) overexpression in the sera of pregnant women has been linked to preeclampsia. Researchers discovered that miR-155 acts during pregnancy by down-regulating and reducing the cysteine-rich angiogenic inducer 61 (CYR61), which causes local ischemia as well as oxidative stress.

Salinity impacts on humidification dehumidification (HDH) desalination systems: review.

The use of humidification-dehumidification water desalination technology has been shown to be a practical means of meeting the demand for freshwater. The aim of this review is to investigate the impact of salinity on HDH techniques that have various benefits in terms of both economics and the environment, including the capacity to operate at low temperatures, utilize sustainable energy sources, the need for low maintenance, and straightforward construction requirements. Also, in this review, it is observed that the HDH system's components are strong and capable of treating severely salinized water.

Exergoeconomic and enviroeconomic evaluations of conventional solar still using PCM and electric heater powered by solar energy: an experimental study.

Solar stills are used in distant and arid areas to convert brackish or salty water into potable water fit for human use in a simple, affordable, and effective manner. Even when PCM materials are used, typical solar systems still have minimal production per day. In this study, experimental tests were carried out in order to increase the performance of a single-slope solar still combined with PCM material (paraffin wax) and a solar-powered electric heater.

Molecular detection of pathogenic bacteria in the colonic biopsies from patients with Ulcerative Colitis.

Background/aim: Ulcerative Colitis (UC) is an inflammatory bowel disease which is common in many areas of the world including Egypt. A lot of controversy regarding the pathogenesis of UC exist. The current study is an attempt to detect some pathogenic bacteria in UC patients.

3E enhancement of freshwater productivity of solar still with heater, vibration, and cover cooling.

This study focused on experimentally increasing the productivity of freshwater from solar stills. The performance of a single solar still system could be augmented with the combination of an electric heater, vibration motion, and thermoelectric cooling. The study investigated the effects of combining two of these components and finally combining all of them on freshwater productivity.

Markers of tumor inflammation as prognostic factors for overall survival in patients with advanced pancreatic cancer receiving first-line FOLFIRINOX chemotherapy.

Background: Identifying pretreatment blood markers that distinguish prognostic groups of patients with advanced pancreatic ductal adenocarcinoma (PDAC) under first-line FOLFIRINOX chemotherapy has the potential to improve management of this condition. Aim of this study was to determine the prognostic utility of a range of pretreatment, inflammation-related, blood cell markers in this group of patients.

Material And Methods: Data from a training cohort were analyzed to identify potential pretreatment blood markers correlating to survival outcomes.

A retrospective study of small molecule disorder types of metabolism in paediatric patients in intensive care.

Background: Although inborn errors of metabolism (IEM) are rare individually, collectively IEM cause substantial morbidity and mortality and the diagnosis is challenging.

Aims: To analyse epidemiological and clinical data, final diagnosis and clinical outcomes of patients with a suspected diagnosis of IEM (small molecule disorders type) admitted to a paediatric intensive care unit (PICU).

Methods: We collected and analysed medical records data of all patients admitted to the PICU at Alexandria University Children's Hospital, from January 2010 to December 2014, with a suspected or confirmed diagnosis of small molecule disorders, including clinical presentations, laboratory results and clinical outcomes.