Synthesis, Characterization, and antiviral evaluation of New Chalcone-Based Imidazo[1,2-a]pyridine Derivatives: Insights from in vitro and in silico Anti-HIV studies.

Given the ease of synthetic accessibility and the promising biological profile demonstrated by both imidazo[1,2-a]pyridine and Chalcone derivatives, a series of Chalcone-based imidazo[1,2-a]pyridine derivatives were synthesized and characterized using H NMR, C NMR, Mass Spectrometry and FTIR techniques. Density functional theory (DFT) was employed to investigate the structural and electronic properties, providing insights into potential reactive sites. The synthesized compounds were evaluated in vitro for their antiviral properties against human immunodeficiency virus type-1 (HIV-1) and human immunodeficiency virus type-2 (HIV-2) in MT-4 cells.

Synthesis, crystal structure, and antiviral evaluation of new imidazopyridine-schiff base derivatives: and anti-HIV studies.

A series of Imidazo[1,2-]pyridine-Schiff base derivatives were synthesized and characterized using H NMR, C NMR, Mass Spectrometry and FTIR techniques, and the structure of 4a was further confirmed through single-crystal X-ray diffraction analysis. Density Functional Theory (DFT) has been used to investigate the structural and electronic properties. The synthesized compounds were evaluated for their antiviral activity against human immunodeficiency virus type-1 (HIV-1) and human immunodeficiency virus type-2 (HIV-2) in MT-4 cells.

Various synthesis and biological evaluation of some tri -tetra-substituted imidazoles derivatives: A review.

The imidazole nucleus represents a significant group of heterocyclic molecules with diverse significance in the modern world due to its exploration potential and various pharmacological applications. The relevance of imidazole and its derivatives has gained popularity in recent years, especially in the production of commercial drugs and the treatment of various conditions. The imidazole nucleus is present in many natural compounds and widely distributed in essential amino acids, such as l-histidine, whose derivatives exhibit powerful pharmacological properties.

Synthesis, Characterizations, and Quantum Chemical Investigations on Imidazo[1,2-]pyrimidine-Schiff Base Derivative: ()-2-Phenyl--(thiophen-2-ylmethylene)imidazo[1,2-]pyrimidin-3-amine.

In this study, ()-2-phenyl--(thiophen-2-ylmethylene)imidazo[1,2-]pyrimidin-3-amine is synthesized, and detailed spectral characterizations using H NMR, C NMR, mass, and Fourier transform infrared (FT-IR) spectroscopy were performed. The optimized geometry was computed using the density functional theory method at the B3LYP/6-311++G(d,p) basis set. The theoretical FT-IR and NMR (H and C) analysis are agreed to validate the structural assignment made for .

Design, synthesis, and computational studies of novel imidazo[1,2-]pyrimidine derivatives as potential dual inhibitors of hACE2 and spike protein for blocking SARS-CoV-2 cell entry.

In the present work, a new series of imidazo[1,2-]pyrimidine Schiff base derivatives have been obtained using an easy and conventional synthetic route. The synthesized compounds were spectroscopically characterized using H, C NMR, LC-MS(ESI), and FT-IR techniques. Green metric calculations indicate adherence to several green chemistry principles.

UV/Vis Light Induced Degradation of Oxytetracycline Hydrochloride Mediated byCo-TiO Nanoparticles.

Pharmaceuticals, especially antibiotics, constitute an important group of aquatic contaminants given their environmental impact. Specifically, tetracycline antibiotics (TCs) are produced in great amounts for the treatment of bacterial infections in both human and veterinary medicine. Several studies have shown that, among all antibiotics, oxytetracycline hydrochloride (OTC HCl) is one of the most frequently detected TCs in soil and surface water.

Elucidation of oxidized products of Chloridazon in advanced oxidation processes using a liquid chromatography/negative electrospray ionization tandem mass spectrometric technique.

Rationale: 5-Amino-4-chloro-2-phenyl-3(2H)-pyridazone (Chloridazon) is an important systemic herbicide; its transformation by different Advanced Oxidation Processes could result in the formation of different and complex products. These products, that need to be identified, may present a more toxic effect than the parent compound.

Methods: The exact and unequivocal structural characterization of the detected by-products of Chloridazon was performed by in-depth analysis of the liquid chromatography/negative electrospray ionization tandem mass spectrometric (LC/ESI+/MS(2) ) fragmentation.