Publications by authors named "Mohamed Ayoub"
Article Synopsis
- The CTO-ARC identified the need for standardized definitions in chronic total occlusion (CTO) procedures to avoid bias in attributing complications to different crossing strategies.
- A study analyzed data from 8,673 patients in the European Registry of Chronic Total Occlusions, finding that the antegrade approach was used in 79.2% of cases, while retrograde was used in 20.8%.
- Results showed that alternative antegrade crossing had lower technical success rates and higher complication rates compared to true antegrade and retrograde methods, though it was primarily used as a rescue strategy in most instances.
Article Synopsis
- The study evaluates the impact of right bundle branch block (RBBB) and left bundle branch block (LBBB) on the prognosis of patients with cardiogenic shock (CS), focusing on 30-day mortality rates.
- It involved 248 adult patients from an ICU in Germany, finding that those with RBBB had the highest mortality at 72.5%, compared to 52.9% for LBBB and 50.0% for no block.
- RBBB significantly predicted increased mortality even after adjusting for key health indicators, while LBBB showed no significant association with mortality outcomes.
Objective: This study investigates the prevalence and prognostic impact of diastolic dysfunction (DD) in patients hospitalized with heart failure (HF) with mildly reduced ejection fraction (HFmrEF) in sinus rhythm.
Background: Data regarding the prognostic impact of DD in patients with HFmrEF is limited.
Methods: From 2016 to 2022, all patients hospitalized with HFmrEF (i.
Objective: The study investigates the characteristics and prognostic impact of different heart failure (HF) etiologies in patients with heart failure with mildly reduced ejection fraction (HFmrEF).
Background: Data regarding the characterization of patients with HFmrEF and their outcomes is scarce.
Methods: Consecutive patients with HFmrEF (i.
Aims: The study investigates the prognosis of atrial fibrillation (AF) in patients with heart failure with mildly reduced ejection fraction (HFmrEF). Data concerning the prognostic impact of AF in patients with HFmrEF is scarce.
Methods And Results: Consecutive patients with HFmrEF [i.
Article Synopsis
- Bifurcation involvement in chronic total occlusion (CTO) percutaneous coronary intervention (PCI) is a significant challenge, but this factor hasn't been widely studied or included in existing scoring systems.
- An analysis of 3,948 CTO-PCI procedures from 92 European centers revealed that 33% of these cases involved bifurcation lesions, which were generally more complex and required more sophisticated devices, resulting in higher radiation and contrast exposure.
- Despite comparable overall technical success rates between bifurcation and non-bifurcation lesions, bifurcation lesions located within the CTO segment faced significantly lower success rates, making it crucial to consider their presence in future PCI assessments.
Article Synopsis
- The study looked at how tricuspid regurgitation (TR), a heart problem, affects patients who are in cardiogenic shock (CS), which is a serious condition where the heart can't pump enough blood.
- Researchers checked medical records and used special tests to see how different levels of TR influenced how long patients survived after 30 days.
- They found that patients with severe TR had a higher chance of dying within 30 days compared to those with less severe TR, especially in patients without a heart attack.
Article Synopsis
- The study examines how previous left ventricular ejection fraction (LVEF) affects prognosis in patients with mildly reduced ejection fraction (HFmrEF) heart failure, a condition often overlooked in terms of prognostic impact.
- It retrospectively analyzed 689 patients from 2016 to 2022, categorizing them into three groups based on changes in LVEF: stable, improved, and deteriorated.
- Results showed no significant differences in all-cause mortality or hospital readmissions among the groups at 12 and 30 months, indicating that changes in LVEF do not significantly influence patient outcomes in this population.
Article Synopsis
- Mitral valve regurgitation (MR) is prevalent among patients with mildly reduced ejection fraction heart failure (HFmrEF), yet data on its impact is limited.
- A study of over 2,000 hospitalized HFmrEF patients found that those with MR had significantly higher risk of all-cause mortality and hospital readmissions for worsening heart failure compared to those without MR.
- The findings also indicated that the severity of MR correlates with increased mortality risk, and secondary MR is associated with better outcomes than primary MR.
Background: Percutaneous coronary interventions (PCI) of chronic total occlusions (CTO) have reached high procedural success rates thanks to dedicated equipment, evolving techniques, and worldwide adoption of state-of-the-art crossing algorithms.
Aims: We report the contemporary results of CTO PCIs performed by a large European community of experienced interventionalists. Furthermore, we investigated the impact of different risk factors for procedural major adverse cardiac and cerebrovascular events (MACCE) and trends of employment of specific devices like dual lumen microcatheters, guiding catheter extensions, intravascular ultrasound and calcium-modifying tools.
Article Synopsis
- * It included 2,184 patients, revealing that those with COPD had a higher risk of all-cause mortality (45% vs. 30%) and re-hospitalization due to worsening heart failure compared to those without COPD.
- * The findings suggest that COPD significantly worsens outcomes for patients hospitalized with HFmrEF, indicating a need for targeted management strategies for this population.
Article Synopsis
- Cardiac remodeling happens in people with heart failure (HF) and helps doctors see how serious the disease is.
- A study looked at 1881 patients with a specific type of heart failure (called HFmrEF) from 2016 to 2022 to see how septal hypertrophy (a condition where part of the heart muscle gets thicker) affected them.
- Although having septal hypertrophy wasn't linked to higher death rates, it was connected to a higher chance of being hospitalized again due to heart problems in the following months.
Article Synopsis
- This study examines the effectiveness of NT-proBNP as a biomarker for diagnosing and predicting outcomes in patients with heart failure and mildly reduced ejection fraction (HFmrEF), focusing on their kidney function (eGFR).
- Among the 755 patients analyzed, those with acute decompensated heart failure (ADHF) showed significantly higher NT-proBNP levels compared to those without, indicating its potential as a diagnostic tool.
- Higher NT-proBNP levels (> 3946 pg/mL) were linked to increased rates of death over 30 months, but its predictive value was diminished in patients with severely reduced kidney function (eGFR < 30 mL/min).
We aimed to investigate the safety, feasibility, and long-term results of drug-eluting stent implantation before covered stents for treating coronary artery perforation (CAP). Between 2015 and 2020, 12,733 patients undergoing percutaneous coronary intervention (PCI) were retrospectively analyzed. The primary endpoint was 1-year target lesion revascularization (TLR), whereas secondary endpoints included the rate of major adverse cardiac and cerebrovascular events (MACCE) and all-cause death at 1 year.
View Article and Find Full Text PDFAssociation of body mass index with 30-day all-cause mortality in cardiogenic shock.
Nutr Metab Cardiovasc Dis
February 2024
Background And Aims: This study investigates the prognostic impact of body mass index (BMI) on the risk of 30-day all-cause mortality in patients with cardiogenic shock (CS). Due to ongoing epidemiological developments, the characteristics of patients with cardiovascular disease are consistently changing. Especially increasing rates of obesity and associated comorbidities have been observed.
View Article and Find Full Text PDFPrognostic impact of acute decompensated heart failure in patients with heart failure with mildly reduced ejection fraction.
Eur Heart J Acute Cardiovasc Care
February 2024
Article Synopsis
- This study looked at how acute decompensated heart failure (ADHF) affects patients who have heart failure with mildly reduced ejection fraction (HFmrEF).
- Researchers found that patients with ADHF had a much higher chance of dying or being hospitalized again compared to those without ADHF.
- The conclusion is that having ADHF is common and makes health outcomes worse for patients with HFmrEF.
Article Synopsis
- This study assesses the predictive value of the tricuspid annular plane systolic excursion (TAPSE) and its ratio to pulmonary artery systolic pressure (PASP) in patients experiencing cardiogenic shock (CS).
- The research involved analyzing 90 patients admitted for CS over a two-year period and found that both TAPSE and the TAPSE/PASP ratio could predict 30-day mortality, particularly with lower values indicating worse outcomes.
- However, while the TAPSE <18 mm was a significant predictor of 30-day all-cause mortality, the TAPSE/PASP ratio did not enhance mortality risk prediction when adjusted for other variables.
Clinical outcomes in patients with reduced left ventricular systolic function undergoing rotational atherectomy (RA) for percutaneous coronary intervention (PCI) remain understudied. Our study sought to evaluate the impact of RA-PCI in patients with LV systolic dysfunction on long-term outcomes. Between 2015 and 2019, 4941 patients with reduced LV function (rEF) undergoing PCI (with or without RA) were included in the hospital database.
View Article and Find Full Text PDFBackground: As a result of improved and novel treatment strategies, the spectrum of patients with cardiovascular disease is consistently changing. Overall, those patients are typically older and characterized by increased burden with comorbidities. Limited data on the prognostic impact of age in cardiogenic shock (CS) is available.
View Article and Find Full Text PDFThis study investigates the prognostic value of the aspartate-to-alanine aminotransferase ratio (i.e., AST/ALT ratio) and bilirubin in patients with cardiogenic shock (CS).
View Article and Find Full Text PDFBackground: The spectrum of patients with cardiogenic shock (CS) has changed significantly over time. CS has become especially more common in the absence of acute myocardial infarction (AMI), while this subset of patients was typically excluded from recent studies. Furthermore the prognostic impact of onset time and onset place due to CS has rarely been investigated.
View Article and Find Full Text PDFPresent research on the influence of gender on the treatment of coronary artery disease (CAD) and the outcome after percutaneous coronary intervention (PCI) is inconsistent. Sex differences in the presentation of CAD and the success after treatment have been described. We intend to compare the male and female sex in the procedure and the long-term outcome of Rotational Atherectomy (RA).
View Article and Find Full Text PDFAlthough previous studies investigated the influence of cardiovascular risk (CVR) factors in patients with acute coronary syndrome, data concerning the effect of CVR factors on the prognosis of patients with cardiogenic shock (CS) is scarce. Consecutive patients with CS were prospectively included from 2019 to 2021. The prognosis of patients with "low CVR" (i.
View Article and Find Full Text PDF