Serum leptin elevation in obese women with PCOs: a continuing controversy.

Purpose: To evaluate leptin levels in a sample of obese women with PCOS and compare the results with obese and non-obese control, to be ultimately correlated with BMI, and insulin sensitivity.

Methods: Leptin and insulin assays by immuno-radiometric method, glucose assay by enzymatic colorimetric method.

Results: Leptin levels were significantly different between obese and non-obese subjects, and were significantly different between insulin resistant and non-insulin resistant obese PCOS, but were not significantly different between obese non-insulin resistant PCOS, and obese controls.