Publications by authors named "Mohamed Ahmed Sobh"
Article Synopsis
- The study investigates the effects of different sources of mesenchymal stem cells (MSCs) on kidney regeneration after acute kidney injury (AKI) induced by cisplatin in rats.
- 120 Sprague-Dawley rats were injected with cisplatin and then treated with rat bone marrow stem cells (rBMSCs), human adipose tissue-derived stem cells (hADSCs), or human amniotic fluid-derived stem cells (hAFSCs) to evaluate their renal recovery effects.
- Results indicated that MSCs from all sources helped improve renal function and tissue damage, with rBMSCs showing the best outcomes in terms of serum creatinine levels and early renal tissue proliferation, while hAFSCs
Background And Objectives: Cisplatin is a nephrotoxic chemotherapeutic agent. So, preventive measures worth to be evaluated. Human amniotic fluid stem cells (hAFSCs) in prevention or amelioration of cisplatin-induced acute kidney injury (AKI) in Sprague-Dawley rates have been tested.
View Article and Find Full Text PDFBackground/aims: Long-term evaluation of cisplatin induced nephrotoxicity and the probable renal protective activities of stem cells are lacking up until now. We evaluated the early and long-term role of human adipose derived mesenchymal stem cells (ADMSCs) in prevention or amelioration of cisplatin induced acute kidney injury (AKI) in Sprague-Dawley rats. For this, we determined the kidney tissue level of oxidative stress markers in conjugation with a renal histopathological scoring system of both acute and chronic renal changes.
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