Publications by authors named "Mohamed Ahmed Abdelmalek"
MircoRNAs predict and modulate responses to chemotherapy in leukemic patients.
Doha El-Sayed Ellakwa Mohamed Ahmed Abdelmalek Mostafa M Mostafa Takwa E Ellakwa Al-Hassan Soliman Wadan
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Leukemia covers a broad category of cancer malignancies that specifically affect bone marrow and blood cells. While different kinds of leukemia have been identified, effective treatments are still lacking for most forms, and even those treatments considered effective can lead to relapses. MicroRNAs, or miRNAs, are short endogenous non-coding single-stranded RNAs that help control the epigenetics of gene expression.
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- - MiRNAs are small non-coding RNA molecules that regulate gene expression by binding to mRNA, leading to its degradation or repression, with their biogenesis involving several detailed steps such as transcription and processing.
- - Colorectal cancer, a common and serious disease with low early diagnosis rates and high metastasis, is influenced by genetic and epigenetic factors, especially miRNAs, which can act as tumor suppressors or oncogenes depending on their target genes.
- - MiRNAs show promise as biomarkers for colorectal cancer due to their stability and ease of detection in body fluids, enabling differentiation between cancer patients and healthy individuals, predicting cancer stage, and monitoring responses to treatment.