Publications by authors named "Mohamed Abdelkarim"

Introduction: Hypertension and dyslipidemia are common contributors to cardiovascular disease (CVD), often occurring together. Effectively Managing both is key to reducing mortality and morbidity, but complex regimens reduce adherence.

Aim: This study investigated the comparative efficacy and safety of a three-drug regimen (TAR) containing telmisartan, amlodipine, and rosuvastatin against two-drug combinations (TA and TR) for managing hypertension and dyslipidemia.

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Cure rates for acute myeloid leukemia (AML) remain suboptimal; thus, new treatment strategies are needed for this deadly disease. Artemisia campestris leaves hold significant value in traditional medicine. Despite extensive research conducted on this plant globally, the specific anti-AML properties of the leaves have received limited investigation.

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Background: Artemisia campestris L. (AC) leaves are widely recognized for their importance in traditional medicine. Despite the considerable amount of research conducted on this plant overworld, the chemical composition and the biological activity of the leaves grown in Tunisia remains poorly investigated.

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Post-weld heat treatment (PWHT) and solid-state thermomechanical treatment (TMT) via friction stir processing (FSP) have been shown to enhance the mechanical properties of aluminum alloys. The current work investigates the effects of PWHT and TMT on the microstructure and mechanical performance of AA6082-T6 welded butt joints welded using the MIG process. The 5 mm thick AA 6082-T6 plates were joined in butt configuration using MIG welding with ER 5356 filler wire, 120 A current, 0.

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Welding of dissimilar aluminum alloys has been widely used in many industrial applications. However, the selection of filler type still attracts significant interest in the welding research area. The present work concerns the effect of filler metal on the microstructure and corrosion of weld joints of dissimilar aluminum alloys.

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Ultrasound imaging is commonly used to aid in fetal development. It has the advantage of being real-time, low-cost, non-invasive, and easy to use. However, fetal organ detection is a challenging task for obstetricians, it depends on several factors, such as the position of the fetus, the habitus of the mother, and the imaging technique.

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Venoms are a rich source of bioactive compounds, and among them is leberagin-C (Leb-C), a disintegrin-like protein derived from the venom of snakes. Leb-C has shown promising inhibitory effects on platelet aggregation. Previous studies have demonstrated that this SECD protein specifically targets α5β1, αvβ3, and αvβ6 integrins through a mimic mechanism of RGD disintegrins.

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Emphysematous epididymo-orchitis is a rare and potentially fatal infection marked by the presence of gas in the epididymis and testicular tissue. Here, we describe the case of a 49-year-old male with a known past medical history of diabetes and hypertension who presented with right inguinoscrotal swelling and severe tenderness. An urgent scrotal ultrasound was obtained and revealed a fluid-filled avascular mass.

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The effects of post heat treatment atmosphere on microstructure and corrosion resistance of duplex stainless steel welded joints were investigated. Post weld heat treatment (PWHT) was carried out with and without protective atmospheres. Nitrogen and argon are used as protective gases individually.

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This study investigates the effect of tool pin eccentricity and welding speed on the grain structure, crystallographic texture, and mechanical properties of friction stir welded (FSWed) AA5754-H24. Three tool pin eccentricities of 0, 0.2, and 0.

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The motivation for the current study was to improve the wear and frictional properties of Al, Al-AlO, and SiC MMCs through HPT processing. The wear test using a tungsten carbide (WC) ball was carried out for different PM and HPT-processed Al and MMC samples. The effect of the sample processing methods on the wear rate, friction, and wear surface morphology was thoroughly investigated.

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Al-AlO and SiC metal matrix composites (MMCs) samples with different volume fractions up to 20% were produced by high-pressure torsion (HPT) using 10 GPa for 30 revolutions of Al-AlO, and SiC and powder metallurgy (PM). The effect of the processing method of micro-size Al MMCs on the density, microstructure evolution, mechanical properties, and tensile fracture mode was thoroughly investigated. HPT processing produces fully dense samples relative to those produced using powder metallurgy (PM).

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The influence of the number of passes and the tube materials on the microstructural evolution, mechanical properties, and wear behavior of Cu and brass tubes after parallel tubular channel angular pressing (PTCAP) was investigated. The grain size decreased to final grain sizes of 138.6 nm and 142.

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and dermatophyte infections are difficult to treat due to increasing antifungal drugs resistance such as fluconazole, as well as the emergence of multi-resistance in clinical bacteria. Here, we first synthesized silver nanoparticles using aqueous fruit extracts from subsp. (L.

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Multiple myeloma (MM) is an incurable plasma cell malignancy with frequent patient relapse due to innate or acquired drug resistance. Cholesterol metabolism is reported to be altered in MM; therefore, we investigated the potential anti-myeloma activity of two cholesterol derivatives: the 5,6 α- and 5,6 β-epoxycholesterol (EC) isomers. To this end, viability assays were used, and isomers were shown to exhibit important anti-tumor activity in vitro in JJN3 and U266 human myeloma cell lines (HMCLs) and ex vivo in myeloma patients' sorted CD138+ malignant cells.

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In this case report we describe an unusual presentation of severe acute papillary necrosis in a COVID-19-positive patient. An emergency flexible ureteroscopy greatly helped in the establishment of the diagnosis. In the international literature, there is a paucity of intraoperative endoscopic images representing severe renal papillary necrosis.

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Article Synopsis
  • Echium arenarium Guss, a Mediterranean plant known for its healing properties, was found to have strong antioxidant, antibacterial, and antiparasitic effects, but its potential anti-cancer effects were previously unexplored.
  • This study examined the cytotoxic effects and apoptosis pathways of root (EARE) and aerial part (EAAPE) extracts on the U266 human multiple myeloma cell line, revealing that EARE was more effective in reducing cell viability than EAAPE.
  • The research indicated that both extracts induced significant apoptosis in U266 cells by affecting mitochondrial membrane potential and activating caspase pathways, with EARE showing higher total phenolic compounds, which may contribute to its anti-cancer properties.
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Doxorubicin (DOX) exhibits a wide-ranging spectrum of antitumor activities which maintain its clinical use despite its devastating impact on highly proliferating cells. The present work was designed to develop a new approach which aims to protect male germ cells from DOX cytotoxicity. Thus, an assessment of the protective potential of a new thioamide analog (thiocyanoacetamide; TA) compared to selenium (Se) was performed in rat sperms exposed to DOX in vitro.

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Background: Vascular endothelial growth factor (VEGF) is a multifunctional cytokine that has important roles in angiogenesis. Our knowledge of the significance of VEGF isoforms in human cancer remains incomplete.

Methods: Bioluminescence imaging and transcriptomic analysis were used to study the colonisation capacity of the human breast cancer cells MDA-MB-231 controlling or overexpressing the VEGF165 or VEGF189 isoform (named cV-B, V165-B and V189-B, respectively) in nude mice.

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The progress in bone cancer surgery and multimodal treatment concept achieve only modest improvement in the overall survival, due to failure in clearing out residual cancer cells at the surgical margin and extreme side-effects of adjuvant postoperative treatments. Our study aims to propose a new method based on cyclodextrin polymer (polyCD) functionalized hydroxyapatite (HA) for achieving a high local drug concentration with a sustained release profile and a better control of residual malignant cells via local drug delivery and promotion of the reconstruction of bone defects. PolyCD, a versatile carrier for therapeutic molecules, can be incorporated into HA (bone regeneration scaffold) through thermal treatment.

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Metastasis, a fatal complication of breast cancer, does not fully benefit from available therapies. In this study, we investigated whether ATIP3, the major product of 8p22 MTUS1 gene, may be a novel biomarker and therapeutic target for metastatic breast tumors. We show that ATIP3 is a prognostic marker for overall survival among patients with breast cancer.

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Statins and bisphosphonates are two distinct classes of isoprenoid pathway inhibitors targeting downstream enzyme to HMG-CoA reductase (upstream enzyme) and farnesyl-pyrophosphate synthase, respectively. Here, we studied fluvastatin (Fluva) and zoledronate (Zol), representative molecules of each class, respectively. In vivo metastatic potentials of both molecules were assessed.

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Breast cancer metastasis is a leading cause of death by malignancy in women worldwide. Efforts are being made to further characterize the rate-limiting steps of cancer metastasis, i.e.

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