Medicinal Chemistry Gone Wild.

Earth is currently experiencing a mass extinction event. The flora and fauna of our planet are experiencing mass die-offs from a multitude of factors, with wildlife disease emerging as one parameter where medicinal chemists are equipped to intervene. While contemporary medicinal chemistry focuses on human health, many traditional pharmaceutical companies have historic roots in human health, animal health, and plant health.

Phenolic Profiles, Antihyperglycemic, Anti-Diabetic, and Antioxidant Properties of Egyptian Leaves Extract: An In Vivo Study.

This study aimed to investigate the phenolic and antioxidant properties of Egyptian leaves extract (SOE) while comparing the antihyperglycemic efficacy of SOE with that of conventional medicines (glibenclamide) in vivo as a substitution for insulin-deficient patients. Total phenolic (TPC) and flavonoid contents (TFC) in SOE contributed around 127.66 ± 0.

Effect of narrow spectral filter position on the characteristics of active similariton mode-locked femtosecond fiber laser.

A significant change in active similariton characteristics, both numerically and experimentally, is observed as a function of the location of the lumped spectral filter. The closer the spectral filter is to the input of the Yb(3+)-doped fiber, the shorter the de-chirped pulse width. The peak power of the de-chirped pulse has its maximum value at a certain location of the spectral filter.

Steady and oscillating multiple dissipative solitons in normal-dispersion mode-locked Yb-doped fiber laser.

Multiple dissipative solitons are numerically studied in the normal-cavity-dispersion Yb-doped fiber laser. Soliton pairs and triplets of different types are found in parameter domain where single soliton mode-locking is unstable. Similar scenario is found for soliton pair and triplet: an additional weak soliton supplements already existing solitons, then with increasing gain the solitons start oscillating and at higher gain the soliton complex becomes stable.

Properties and stability limits of an optimized mode-locked Yb-doped femtosecond fiber laser.

Stable mode-locked operation in a simple normal-cavity-dispersion laser oscillator that consists of only Yb-doped fiber and saturable absorber is studied. The Yb-doped fiber design parameters: group velocity dispersion (GVD), nonlinearity coefficient, bandwidth (Yb-BW), length and gain are considered to be the controlling parameters of the laser cavity. The pulse characteristics such as the temporal width, spectrum and pulse energy as a function of these elements are reported here.