Publications by authors named "Mohamed AbdelAziz"

Introduction: This study aimed to evaluate the clinical and radiographic outcomes of full pulpotomy in mandibular molar teeth with symptomatic irreversible pulpitis. It compared class I and class II cavity defects and correlated these outcomes with the quantification of two biomolecules (TNF-α and MMP-9) using two types of pulpotomy dressing materials (MTA+ and Well-Root PT).

Methodology: Sixty patients were selected and categorized based on cavity class.

View Article and Find Full Text PDF

A new series of benzimidazole-oxadiazole-small molecules were synthesized and confirmed with various spectroscopic techniques. The prepared derivatives exhibited significant inhibitory activity against the proliferation of different cancer cells. The benzimidazoles 10f, 10 h, 10 g, and 10i showed broad anticancer activity with no selectivity in five-dose assays.

View Article and Find Full Text PDF

Background: Overweight and obese children are risky for developing chronic cardiovascular disorders. Heart rate variability is a valuable indicator of the cardiovascular health.

Aim: To outline the impact of supplementation of omega-3 on the variability of the heart rate.

View Article and Find Full Text PDF

Electric vehicle (EV) production is pivotal in achieving environmental sustainability by reducing greenhouse gas emissions and air pollution. Since the weight of electric vehicles directly influences the energy consumption and driving range of the vehicle, innovative engineers face a significant challenge in designing an optimized vehicle chassis that remains robust under complex loading conditions. This paper focuses on the dynamic analysis of an EV chassis subjected to transient suspension forces due to hitting speed bumps and proposes a load factor between static and dynamic loads.

View Article and Find Full Text PDF

The mammalian Hippo kinases, MST1 and MST2, regulate organ development and suppress tumor formation by balancing cell proliferation and death. In macrophages, inflammasomes detect molecular patterns from invading pathogens or damaged host cells and trigger programmed cell death. In addition to lytic pyroptosis, the signatures associated with apoptosis are induced by inflammasome activation, but how the inflammasomes coordinate different cell death processes remains unclear.

View Article and Find Full Text PDF

This study identifies the secondary metabolites from Alternaria alternate and evaluates their ACE-2: Spike RBD (SARS-CoV-2) inhibitory activity confirmed via immunoblotting in human lung microvascular endothelial cells. In addition, their in vitro anti-inflammatory potential was assessed using a cell-based assay in LPS-treated RAW 264.7 macrophage cells.

View Article and Find Full Text PDF

Wool is the most widely used proteinic natural fiber in the clothing industry by virtue of its versatile properties. Unfortunately, wool, as a natural fiber, is more susceptible to attack by microorganisms and moths, which may cause harm to the fiber and human health. That is why the antimicrobial and mothproof finishing of natural textiles is of prime importance to the textile and clothing industry.

View Article and Find Full Text PDF

Background: Hepatitis B virus (HBV) is a global health issue, particularly among healthcare personnel, including students because of its occupational exposure pattern. Healthcare Workers and medical students are recommended to have better knowledge, attitudes and good practices and vaccination toward infection control in general and HBV in particular. This study aimed to assess the knowledge, attitudes, and practices of medical students from North Sudan regarding HBV and its vaccination coverage.

View Article and Find Full Text PDF

The COVID-19 pandemic has caused significant mortality and morbidity for millions of people. Severe Acute Respiratory Syndrome-2 (SARS-CoV-2) virus is capable of causing severe and fatal diseases. We evaluated the antiviral properties of Aspergillus tamarii SP73-EGY isolate extract against low pathogenic coronavirus (229E), Adeno-7- and Herpes-2 viruses.

View Article and Find Full Text PDF
Article Synopsis
  • Shape Memory Polymers (SMPs) have great potential for medical applications, but their usage has been limited due to challenges in processing and production.
  • This study introduces a thermal drawing technique to create Shape Memory Polymer Fibers (SMPFs) that allow for programmable stiffness and shape control, specifically designed for medical devices.
  • The research explores various applications of these SMPFs in medical devices like adjustable catheters, neural interfaces, and cochlear implants, demonstrating their versatility and potential in programmable mechanical functions.
View Article and Find Full Text PDF

Nile tilapia () and European sea bass () are economically significant species in Mediterranean countries, serving essential roles in the aquaculture industry due to high market demand and nutritional value. They experience substantial losses from bacterial pathogens and , particularly at the onset of the summer season. The immune mechanisms involved in fish infections by and remain poorly understood.

View Article and Find Full Text PDF

The rising incidence of vulvovaginal candidiasis (VVC) has been leading to the development of alternative antifungal therapies. This study aimed to develop a topical chitosan-oleic acid nanoparticle (CH-OA-NP) cream loaded with lemon peel essential oil (LPEO) for VVC treatment. The characterization of the optimal nanoparticle formulation (F4: 10 g/L CH, 2:1 OA/LPEO ratio) showed high encapsulation efficiency, stability, and controlled release.

View Article and Find Full Text PDF

Background And Objective: Recent studies have proposed computed tomography (CT) criteria for posterior ligamentous complex (PLC) injury: disrupted if ≥2 CT findings, indeterminate if single finding, and intact if 0 CT findings. The study aims to validate the CT criteria for PLC injury externally.

Methods: Three level 1 trauma centers enrolled 614 consecutive patients with acute thoracolumbar fractures (T1-L5) who received CT and MRI.

View Article and Find Full Text PDF

Infections attributable to respiratory syncytial virus (RSV) are a major cause of hospitalization among young children worldwide. Despite substantial clinical and economic burden, real-world data associated with RSV infections in the United Arab Emirates (UAE) are limited. This study aimed to assess among children (<18 years) diagnosed with RSV the epidemiology, seasonality, comorbidities, treatment patterns, length of hospital stay, healthcare resource utilization (HCRU), and costs associated with pediatric infection in Dubai, UAE.

View Article and Find Full Text PDF

Background: Drug-coated balloons (DCB) have promising results in the management of in-stent restenosis (ISR), still their role remains a major challenge, and not well established in contemporary clinical practice.

Aims: To provide a comprehensive appraisal of the efficacy and safety of DCBs in patients with in-stent restenosis (ISR).

Methods: We searched PubMed, Scopus, web of Science, Ovid, and Cochrane Central from inception until 30 March, 2023.

View Article and Find Full Text PDF

The experience of pain is complex, involving both sensory and affective components, yet the underlying neural mechanisms remain elusive. Here, we show that formalin-induced pain behaviors coincide with increased responses in glutamatergic neurons within the anterior paraventricular nucleus of the thalamus (PVA). Furthermore, we describe non-overlapping subpopulations of PVAVgluT2 neurons involved in sensory and affective pain processing, whose activity varies across different pain states.

View Article and Find Full Text PDF

Indoor Air Quality (IAQ) is very important topic in any radioisotope production facility. It is mandatory for some operators to be available behind hot cell that produce radioisotope to practice some tasks concerning maintenance, dosimetry and operation. One of these tasks is redundant transferring Radioiodine from cell to quality control lab and vice versa for measurements.

View Article and Find Full Text PDF

Background: Non-communicable diseases emerge as major public health challenges with increasing prevalence and mortality. The armed conflict in Sudan has resulted in the displacement of 6.8 million people, putting a significant strain on the health sector in the displacement areas.

View Article and Find Full Text PDF

Cancer is the second leading cause of death globally, surpassed only by heart disease. Moreover, bacterial infections remain a significant global health burden, contributing substantially to morbidity and mortality, especially among hospitalized patients. EGFR has emerged as a prime therapeutic target due to its pivotal role in driving uncontrolled cell growth and survival across numerous cancer types.

View Article and Find Full Text PDF
Article Synopsis
  • Indole-based heterocyclic compounds are significant in drug development for their pharmacological properties, and this study focused on synthesizing C3-indole derivatives linked to various heterocycles.
  • * The newly synthesized compounds were analyzed using multiple spectroscopy techniques and tested for antimicrobial activity against several microbes, with specific compounds showing the highest effectiveness.
  • * Molecular docking studies revealed that particular structural features of the indole derivatives were key in inhibiting DNA gyrase B enzymes in different bacteria, offering insights for future antimicrobial drug development.
View Article and Find Full Text PDF
Article Synopsis
  • Diabetic retinopathy (DR) is a significant complication of diabetes mellitus (DM) and this study aimed to evaluate the knowledge, attitudes, and practices regarding DR among diabetic patients in Dongola, Sudan.
  • Conducted from September 2022 to June 2023 with 241 participants at Al-Jemaih Diabetic Center, the study revealed that over half had good knowledge about DR, with urban residency linked to better understanding, while 79.3% had a favorable attitude.
  • Despite positive knowledge and attitudes, only 27.8% had regular eye check-ups, mainly due to the misconception that these check-ups were unnecessary, highlighting a need for better education on DR's management.
View Article and Find Full Text PDF

Ruthenium complexes incorporating 2,2' : 6',2''-terpyridine ligands have emerged as promising candidates due to their versatile biological activities including DNA-binding, anti-inflammatory, antimicrobial, and anticancer properties. In this study, three new 4'-functionalized bis(terpyridine) Ru(II) complexes were synthesized. These complexes feature one ligand as 4-(2,2' : 6',2''-terpyridine-4'-yl) benzoic acid and the second ligand as either 4'-(2-thienyl)-2,2' : 6',2''-terpyridine, 4'-(3,4-dimethoxyphenyl)-2,2' : 6',2''-terpyridine, or 4'-(4-dimethylaminophenyl)-2,2' : 6',2''-terpyridine.

View Article and Find Full Text PDF

Quorum sensing (QS) is a bacterial cell-to-cell communication mechanism that plays an essential role in bacterial pathogenesis. QS governs bacterial behavior and controls biofilm formation, which in turn contributes to antibiotic resistance. Therefore, identifying and synthesizing novel compounds to overcome QS and inhibit biofilm formation are essential.

View Article and Find Full Text PDF
Article Synopsis
  • * Magnetic resonance imaging (MRI) is a promising radiation-free option for cardiovascular interventions but currently lacks compatible instruments for effective use.
  • * The introduction of a new thermal drawing platform allows for the rapid development of affordable MRI-compatible catheter systems, demonstrating similar mechanical properties to existing devices and paving the way for innovation in catheter technologies for cardiovascular interventions.
View Article and Find Full Text PDF