Prevalence of Quorum Sensing and Virulence Factor Genes Among Isolated from Patients Suffering from Different Infections and Their Association with Antimicrobial Resistance.

Purpose: Antimicrobial resistance and virulence genes play important roles in increasing the severity of infections, especially in hospitalized patients with high antibiotic pressure. Most genes that encode virulence factors are controlled and regulated by the quorum sensing (QS) system. The aim of this study was to investigate the frequency of some virulence genes ( genes) and their association with antibiotic resistance.

Bioactive fluorenes. Part III: 2,7-dichloro-9-fluorene-based thiazolidinone and azetidinone analogues as anticancer and antimicrobial against multidrug resistant strains agents.

Background: Thiazoles, thiazolidinones and azetidinones are highly ranked amongst natural and synthetic heterocyclic derivatives due to their great pharmaceutical potential.

Results: New thiazolidinone and azetidinone class of bioactive agents based on 4-(2,7-dichloro-9-fluoren-4-yl)thiazole moiety have been successfully synthesized. 4-(2,7-dichloro-9-fluoren-4-yl)thiazol-2-amine was synthesized and allowed to react with various aryl/heteroaryl aldehydes to afford the corresponding Schiff base intermediates.

Bioactive fluorenes. part I. Synthesis, pharmacological study and molecular docking of novel dihydrofolate reductase inhibitors based-2,7-dichlorofluorene.

In this study, a new series of 2,7-dichloro-4-(2-substituted-amino acetyl)fluorene derivatives were synthesized, characterized and evaluated for their antimicrobial activity and screened for cytotoxic activity against human lung carcinoma (A-549) and human breast carcinoma (MCF-7) cell lines. Most of the synthesized compounds displayed significant activity against A-549 and MCF-7 cell lines when compared to 5-fluorouracil (5-FU), which was used as a reference drug. In addition, some of these reported novel compounds exhibited promising antibacterial and antifungal properties.