Bioactive secondary metabolites from fungal endophytes, and , associated with and : an study.

Two pure fungal strains were isolated and identified from and , namely, (OR673586) and (OR673589), respectively. The extract and fractions of secondary metabolites of each fungus were evaluated for antioxidant, anti-inflammatory, antimicrobial, antibiofilm, antidiabetic, and cytotoxic activities. The chloroform fraction of showed potent cytotoxic activity (IC = 7.

Nutritional, Antioxidant, Antimicrobial, and Anticholinesterase Properties of : A Study Supported by Spectroscopic and Computational Investigations.

Dietary fruits and vegetables play a vital role as food and drugs and are the main sources of antioxidant defences against degenerative diseases, such as brain dysfunctions, cardiovascular diseases, immune system deteriorations, and cancers, brought on by oxidative damage. is a significant herbal remedy used in conventional medicine to recover lost strength and power. In this research, the potential value of as a food and drug is researched.

Chemical and Biological Review of Endophytic Fungi Associated with sp. (Moraceae) and In Silico Study of Their Antidiabetic Potential.

The chronic nature of diabetes mellitus motivates the quest for novel agents to improve its management. The scarcity and prior uncontrolled utilization of medicinal plants have encouraged researchers to seek new sources of promising compounds. Recently, endophytes have presented as eco-friendly leading sources for bioactive metabolites.

Phytochemical and in silico studies for potential constituents from as candidates against the SARS-CoV-2 main protease and RNA-dependent RNA polymerase.

In the present study, a new secoiridoid glycoside lisianthoside II , along with seven known compounds were isolated from L. In-silico molecular docking and molecular dynamic simulation against SARS-CoV-2 Main protease (M) and RNA-dependent RNA polymerase (RdRp) were conducted. The affinity docking scores revealed that is the best bound ligand to M active site with binding energy of -14.

New quinolizidine alkaloid and insecticidal activity of and against (Diptera: Culicidae).

Phytochemical investigation of alkaloid fraction led to isolation of one new quinolizidine alkaloid 13-methoxyanagyrine together with six known ones . The insecticidal activity of 70% methanol extract of leaves of , and the isolated alkaloids were assessed against 3 instar larvae of (Diptera: Culicidae) using different concentrations and mortality rate was recorded. extract showed highest mortality rate with median lethal concentration LC 3.

A New Phenolic Alkaloid from Halocnemum strobilaceum Endophytes: Antimicrobial, Antioxidant and Biofilm Inhibitory Activities.

Human infections caused by microbial biofilm formation represent a growing major health threat. A new alkaloid, 3-amino-5-(3-hydroxybutan-2-yl)-4-methylphenol, was isolated from the corn grit culture of the endophytic isolate Penicillium citrinum-314 associated with Halocnemum strobilaceum, a halophyte growing in the Egyptian marshes. The new alkaloid was identified by 1D, 2D-NMR and HR-ESI-MS-MS and given the trivial name halociline.

Neuroprotective effects of , leaves and formononetin on scopolamine-induced dementia.

Five flavonoids were isolated from the ethyl acetate fraction of leaves of ; formononetin , 5-hydroxy-4'-methoxyflavone , genistein , 5-hydroxy-8-(1-hydroxy-1-methyl-ethyl)-2-(4-hydroxyphenyl)-4-furo-[2, 3-]-chromen-4-one and ononin . Additionally, LC-ESI-MS/MS analysis of the ethyl acetate fraction of leaves had led to tentative identification of eighteen compounds. Formononetin, and leaves methanolic extract were evaluated for their neuroprotective activity where formononetin and showed promising neuroprotective activity with reduction in acetylcholine esterase (AchE) enzyme activity and elevation of acetylcholine (Ach) and glutathione(GSH) brain levels and attenuation of dopamine (DA), nor-adrenaline (NA) and malonedialdehyde (MDA) brain level significantly, However leaves methanolic extract didn't attenuate the AchE enzyme activity, DA and NA brain levels.

The pharmacology of the genus Sophora (Fabaceae): An updated review.

Background: The genus Sophora (Fabaceae) represents one of the important medicinal plant genera regarding its chemical constituents and outstanding pharmacological activities.

Purpose: In this review, we surveyed the latest findings on the bioactivities of different Sophora extracts and isolated phytochemicals during the past 8 years (2011-2019) updating the latest review article in 2011. The aim of this review is to focus on the molecular pharmacology of Sophora species to provide the rationale basis for the development of novel drugs.

New nitrogenous compounds from Anisotes trisulcus.

Re-investigation of the methanolic extract of Anisotes trisulcus (Forssk.) Nees aerial parts led to the isolation of two new tricyclic quinazoline alkaloids, 8-amino-7,8,9,11-tetrahydro-6H-pyrido[2,1-b]-quinazoline-2,6-diol (4) and 8-amino-3,6-dihydroxy-7,8,9-trihydro-6H-pyrido[2,1-b]quinazoline-11-one (5), and two quaternary ammonium compounds, (dimethylamino)-N-(hydroxymethyl)-N,N-dimethyl methanaminium chloride (6) and N-[(carboxyamino)methyl]-N,N-dimethyl ethanaminium chloride (7), together with three known compounds, peganine (1), vasicinone (2), and anisotine (3). The structures of these compounds were established on the basis of physical, chemical, and spectral data (UV, IR, MS, 1D and 2D NMR), as well as by comparison with authentic samples.

Two new acetylated flavonoid glycosides from Centaurium spicatum L.

Two new acetylated flavonol glycosides, quercetin 3-O-[(2,4-diacetyl-α-L-rhamnopyranosyl)-(1→6)]-2,4-diacetyl-β-D-galactopyranoside (1) and quercetin 3-O-[(2,4-diacetyl-α-L-rhamnopyranosyl)-(1→6)]-3,4-diacetyl-β-D-galactopyranoside (2), in addition to two known acetylated quercetin glycosides quercetin 3-O-[(2,3,4-triacetyl-α-L-rhamnopyranosyl)-(1→6)-β-D-galactopyranoside (3) and quercetin 3-O-[(2,3,4-triacetyl-α-L-rhamnopyranosyl)-(1→6)-3-acetyl-β-D-galactopyranoside (4), were isolated from the aerial part of Centaurium spicatum (L.) Fritsch (Gentianaceae). Structure elucidation, especially the localization of the acetyl groups, and complete (1)H and (13)C NMR assignments of these biologically active compounds were carried out using one- and two-dimensional NMR measurements, including (1)H- and (13)C-NMR, DEPT-135, H-H COSY, HMQC and HMBC, in addition to HR-FAB/MS experiments.

Rare trisubstituted sesquiterpenes daucanes from the wild Daucus carota.

Phytochemical and biological investigation of the roots of the wild Daucus carota ssp. carota afforded three new and four known compounds, including four sesquiterpenes daucane esters (1-3 [new], and 4), one polyacetylene (5), one sesquiterpene coumarin (6), and sitosterol glucoside. The structures of the new compounds were determined by comprehensive NMR studies, including DEPT, COSY, NOESY, HMQC and HMBC analyses.

Polyol monoterpenes and sesquiterpene lactones from the Pacific Northwest plant Artemisia suksdorfii.

Five new polyol monoterpenes (1-5) and seven new sesquiterpene lactones (6-12), along with five previously identified compounds, were isolated from the aerial parts of Artemisia suksdorfii. The structures of the new compounds were established by high-field NMR techniques (1H, 13C, 1H-1H DEPT, COSY, HMQC, and HMBC) and in case of 6 confirmed by X-ray analysis.

Cyclodextrin-enclosed substances of Brazilian propolis.

By using beta-cyclodextrin-inclusion as a unique technique, an efficient separation of pharmacologically active phenolic compounds from Brazilian propolis was achieved to provide one new compound, 3-(3-hydroxy-3-methyl-butyl)-5-prenyl-4-hydroxycinnamic acid, together with two common cinnamic acid derivatives, artepillin C and capillartemisin A, and two known flavanols, aromadendrin and 3,5,7-trihydroxy-4'-methoxyflavanol.

A new eudesmane derivative from Onopordon ambiguum.

Reinvestigation of Onopordon ambiguum extract afforded a new eudesmane derivative 1, in addition to the known elemanoid derivative 2. The structures of both compounds were determined by spectroscopic techniques, including 1H-, 13C-NMR, DEPT, 1H-1H and 1H-13C COSY analysis.