Alogliptin attenuates cyclophosphamide-induced nephrotoxicity: a novel therapeutic approach through modulating MAP3K/JNK/SMAD3 signaling cascade.

Cyclophosphamide (CP) is widely used as a chemotherapy against various types of cancers. However, CP is accompanied with multiple organ toxicity due to production of reactive oxygen species (ROS), induction of inflammation and consequently apoptosis. Alogliptin (Alo) is a dipeptidyl peptidase 4 (DPP-IV) inhibitor, which is booming as an antidiabetic agent.

Artificial neural network modeling of plasmonic transmission lines.

In this paper, new models based on an artificial neural network (ANN) are developed to predict the propagation characteristics of plasmonic nanostrip and coupled nanostrips transmission lines. The trained ANNs are capable of providing the required propagation characteristics with good accuracy and almost instantaneously. The nonlinear mapping performed by the trained ANNs is written as closed-form expressions, which facilitate the direct use of the results obtained in this research.