Increased IL-17A but decreased IL-27 serum levels in patients with multiple sclerosis.

Background: Effector CD4+ T cell subsets play an important role in Multiple Sclerosis (MS). Interleukin-27 (IL-27) suppresses Th (Th1, Th2 and Th17) cells and dampens autoimmunity and tissue inflammation by promoting the generation of Type 1 regulatory T cells (Tr1).

Objective: To identify the relative levels of IL-27 and IL-17A in MS disease.