The Added-on of Syrup in the Treatment of Chronic Spontaneous Urticaria Resistant to Standard-Dose of Secondary-generation H Antihistamine: A Double-Blind Randomized Clinical Trial.

Background: Although antihistamines are the first-line treatment for chronic spontaneous urticaria (CSU), 50% of patients don't respond to standard doses. In this study, the effectiveness of fruit syrup in combination with antihistamines was assessed in patients with CSU.

Methods: This double-blind randomized clinical trial was conducted in Shiraz between December 2019 and December 2020.