Publications by authors named "Mohamad Kareem Marrache"

Background And Aim: Portal hypertensive gastropathy (PHG) most commonly occurs in the setting of increased portal pressure in patients with cirrhosis. Here, we aimed to understand the correlation between hepatic venous pressure gradient (HVPG) and the presence and severity of PHG in patients with cirrhosis.

Methods: We examined patients with cirrhosis who underwent HVPG measurement at the Medical University of South Carolina between 2014 and 2020.

View Article and Find Full Text PDF

Purpose Of Review: Statins are a class of lipid lower medications used primarily in patients with high-risk cardiovascular disease. Since their development, statins have been considered to be harmful in patients with liver disease, and many of the prescribing information labels consider them to be contraindicated in patients with active liver disease. However, recent studies have shown the contrary, warranting further investigation and discussion.

View Article and Find Full Text PDF

Technologic advancements in the field of therapeutic endoscopy have led to the development of minimally invasive techniques to create GI anastomosis without requiring surgery. Examples of the potential clinical applications include bypassing malignant and benign gastric outlet obstruction, providing access to the pancreatobiliary tree in those who have undergone Roux-en-Y gastric bypass, and relieving pancreatobiliary symptoms in afferent loop syndrome. Endoscopic GI anastomosis is less invasive and less expensive than surgical approaches, result in improved outcomes, and therefore are more appealing to patients and providers.

View Article and Find Full Text PDF
Article Synopsis
  • Bariatric surgery, including procedures like sleeve gastrectomy and Roux-en-Y gastric bypass, is increasingly used to treat obesity but can negatively impact gastroesophageal reflux disease (GERD).
  • Recent evidence indicates sleeve gastrectomy has the highest rates of new GERD cases, while Roux-en-Y gastric bypass and one anastomosis gastric bypass show lower rates; intragastric balloons are also linked to increased GERD risks.
  • Patients considering bariatric surgery might benefit from an endoscopy before the procedure to select the best treatment option, and more research is needed to understand the effects of surgeries like endoscopic sleeve gastroplasty on GERD.
View Article and Find Full Text PDF